CASP12 Antibody

1. Piezo1 plays an important role in the apoptosis of human osteoarthritis-derived chondrocytes through a caspase-12-dependent pathway. PMID:28731145
2. study indicated the potential effect of Casp12 was on the activation of NF-kappaB by the degradation of IkappaBalpha in NPC cells. PMID:28380444
3. CASP12 genotype thus does not influence the phenotype of systemic lupus erythematosus in African-Americans PMID:26973091
4. Endoplasmic reticulum stress may be associated with apoptosis of LECs, resulting in cataract formation in diabetic patients. PMID:27130368
5. Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. PMID:26261584
6. Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children. PMID:26582949
7. We found that RNA interference-induced Caspase-12 silencing increased NOD1, hBD1 and hBD2 expression PMID:25503380
8. conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP PMID:24586588
9. EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis. PMID:24224909
10. Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores. PMID:24515649
11. CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection. PMID:21706251
12. examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product PMID:21872999
13. caspase 12 has acquired deleterious mutations PMID:12054529
14. Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion disorders. PMID:14532116
15. Na/Ca exchanger overexpression activates caspase-12 PMID:15033764
16. Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis PMID:15129283
17. Observational study of genotype prevalence. (HuGE Navigator) PMID:16917906
18. The activation of caspase-9 and depolarization of mitochondrial membrane potential were induced by BIK, which were decreased concomitant with caspase-12 silenced. PMID:17574210
19. proteolytic activity of caspase-12 is confined to its own proenzyme PMID:18332441
20. hRPE cells express a high level of caspase-12S. The regulated expression of caspase-12S suggests that this caspase recruitment domain (CARD)-only protein may be an endogenous dominant negative regulator that modulates inflammatory responses in hRPE cells. PMID:18791174
21. estrogen-mediated inhibition of Csp-12L expression is a built-in mechanism that has evolved to protect females from Listeria monocytogenes infection. PMID:19447924
22. the NOD2/RIP2 pathway has a role in recognition of Yersinia, but caspase-12 does not modulate innate host defense against Y. pestis PMID:19721713
23. The calcium-calpain-caspase-12-caspase-3 cascade is altered in F508del-CFTR expressing cells. PMID:20041182
24. Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy. PMID:20299359
25. Observational study of gene-disease association. (HuGE Navigator) PMID:20299368
26. Observational study of gene-disease association. (HuGE Navigator) PMID:20423816
27. Observational study of gene-disease association. (HuGE Navigator) PMID:20577092
28. Constitutively active forms of caspase-12 (rev-Deltapro1 and rev-Deltapro2) could induce cell death in cells transfected with the corresponding expression vectors. PMID:20646990

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HGNC: 19004

UNIGENE: Hs.476989

KEGG: hsa:100506742

STRING: 9606.ENSP00000424038

OMIM: 608633