CARD16 Antibody

Code: CSB-PA682727LA01HU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IF

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Target Background

Product Details

Uniprot NO.

Q5EG05

Target Names

CARD16

Alternative Names

CAR16_HUMAN antibody; CARD only domain-containing protein 1 antibody; CARD only protein antibody; CARD16 antibody; Caspase recruitment domain family, member 16 antibody; Caspase recruitment domain-containing protein 16 antibody; Caspase-1 dominant-negative inhibitor pseudo-ICE antibody; Caspase-1 inhibitor COP antibody; COP antibody; COP1 antibody; Pseudo interleukin 1 beta converting enzyme antibody; Pseudo interleukin-1 beta converting enzyme antibody; Pseudo interleukin-1beta converting enzyme antibody; PSEUDO-ICE antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Caspase recruitment domain-containing protein 16 protein (1-197AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-4 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunofluorescence staining of Hela cells with CSB-PA682727LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Target Background

Function(From Uniprot)

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Gene References into Functions

Expression of NOX4/p22(phox) as well as ROS production is enhanced by IL-1beta. On the other hand, the use of NOX4 inhibitors decreased IL-1beta-induced collagenase synthesis by chondrocytes. PMID:26521743
Caspase-1-mediated cell death is regulated, at least in part, by the balance of Rip2 and Cop; alterations of this balance may contribute to aberrant caspase-1-mediated pathogenesis in Huntington's disease. PMID:16354923
Cop inhibition of cell death, at least to a certain extent, results from its interference with the activation of caspase-1 and caspase-4. PMID:16920334

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Tissue Specificity

Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.

Database Links

HGNC: 33701

UNIGENE: Hs.348365

KEGG: hsa:114769

STRING: 9606.ENSP00000364858

OMIM: 615680

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