C8G Antibody

Code: CSB-PA004196LA01HU

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20μg50μg100μg

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB

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Target Background

Product Details

Uniprot NO.

P07360

Target Names

C8G

Alternative Names

C8C antibody; C8G antibody; CO8G_HUMAN antibody; Complement component 8 gamma polypeptide antibody; Complement component C8 gamma chain antibody; MGC142186 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Complement component C8 gamma chain protein (21-202AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: C8G antibody at 2µg/ml + Human serum
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 23 kDa
Observed band size: 23 kDa

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Target Background

Function(From Uniprot)

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Gene References into Functions

Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module + low-density lipoprotein receptor class A module + membrane attack complex/perforin domain of C8 beta. PMID:12220191
structure of a C8gamma.laurate complex revealed Y83 and Y131 can move to allow penetration of hydrocarbon chain of laurate into the lower cavity. A Y83W mutation blocked access but had no effect on the ability of C8gamma to enhance C8 cytolytic activity PMID:17452033

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Subcellular Location

Secreted.

Protein Families

Calycin superfamily, Lipocalin family

Database Links

HGNC: 1354

UNIGENE: Hs.1285

KEGG: hsa:733

STRING: 9606.ENSP00000224181

OMIM: 120930

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