C4BPB Antibody

Code: CSB-PA003954ESR2HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC, IP

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Target Background

Product Details

Uniprot NO.

P20851

Target Names

C4BPB

Alternative Names

C4b binding protein beta chain antibody; C4b-binding protein beta chain antibody; C4BP antibody; C4BPB antibody; C4BPB_HUMAN antibody; Complement component 4 binding protein beta antibody; Complement component 4 binding protein beta chain antibody; Complement component 4-binding protein beta antibody; OTTHUMP00000034288 antibody; OTTHUMP00000034289 antibody; OTTHUMP00000034375 antibody; OTTHUMP0000003474 antibody; Proline rich protein antibody; PRP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human C4b-binding protein beta chain protein (18-252AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, IHC, IP

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IP	1:200-1:2000

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol Immunoprecipitation (IP) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA003954ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA003954ESR2HU at dilution of 1:100
Immunoprecipitating C4BPB in HepG2 whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA003954ESR2HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA003954ESR2HU (8μg) + HepG2 whole cell lysate (500μg)
Lane 3: HepG2 whole cell lysate (10μg)

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.

Gene References into Functions

SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB PMID:28278182
Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells. PMID:24064215
crystallographic data on the structure of CD11c/CD18 and prediction of the secondary structure of the C4BP oligomerization domain, we show that epitopes bound by KIM185 in these proteins are unlikely to share any major structural similarity. PMID:21856004
C4BP alpha7beta0 subunit [C4BP alpha7beta0 isoform lacking the beta-chain] induces a semimature, tolerogenic state on human monocyte-derived dendritic cells activated by a proinflammatory stimulus. PMID:23390292
Since FI requires cofactors for its activity we also investigated the binding of purified cofactors C4BP and FH and found acquisition of both proteins, which retained their activity in FI mediated degradation of C3b and C4b. PMID:22514678
Results demonstrate that successful secretion of complement regulatory protein C4b-binding protein beta-chains depends on intracellular complex formation with vitamin K-dependent protein S, but not on the alpha-chains. PMID:20693287
Localized via protein S to the surface of apoptotic cells, C4BP is able to interact with complement protein C4b, thus retaining its physiological role in regulation of complement on the apoptotic cell surface. PMID:12193728
C4BP is composed of seven alpha-chains and a unique beta-chain, each chain comprising repeating complement control protein (CCP) modules, the results suggest that the role of CCP2 in protein S binding is to orient and stabilize CCP1 PMID:12492479
C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation. PMID:15967823
analysis of structural basis for C4b-binding protein interaction with streptococcal M protein PMID:16330538
review of multiple functional roles of the complex of protein S and cd4-binding protein beta chain, such as binding to apoptotoic cells, phagocytosis PMID:17597997
C4BP levels are increased in patients suffering from primary Sjogren's syndrome PMID:19284503