BRD3 Antibody, HRP conjugated

Code: CSB-PA624013HB01HU

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Size:

50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q15059

Target Names

BRD3

Alternative Names

BRD 3 antibody; Brd3 antibody; BRD3_HUMAN antibody; Bromodomain containing 3 antibody; Bromodomain containing protein 3 antibody; Bromodomain-containing protein 3 antibody; KIAA0043 antibody; Open reading frame X antibody; ORFX antibody; RING3 like gene antibody; RING3-like protein antibody; RING3L antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Bromodomain-containing protein 3 protein (356-506AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets.

Gene References into Functions

conclude that BRD3/4 and the FLT3-TAK1/NF-kB pathways collectively control a set of targets that are critically important for the survival of human MLL-AF9 cells PMID:29240787
The bromodomain and extraterminal domain (BET) family consists of BRDT, BRD2, BRD3, and BRD4, each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites. PMID:28945351
Ewing sarcoma may be susceptible to treatment with epigenetic inhibitors blocking BRD3/4 activity and the associated pathognomonic EWS-FLT1 transcriptional program. PMID:26623725
An isoform of BRD3, BRD3R (BRD3 with Reprogramming activity) is a reprogramming factor. PMID:26947130
Here, we identify NCT, a complex comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02), casein kinase II (CKII), and several TAFs, as a regulator of condensin function. PMID:24565511
BRD2, BRD3, and BRD4 interact with gammaretroviral INs and serve as cofactors for murine leukemia virus integration. PMID:24049186
The BRDT gene was not expressed in testicular tissue from patients with Sertoli cells only, whereas the other three genes of the BET family retained expression in all the sperm pathologies. PMID:22035730
the structural basis for GATA1 and Brd3 interaction was described. PMID:21555453
Activated lymphocytes induced by mitogens or antigens express various sets of genes, including those involved in the expression of cytokines, surface molecules, and nuclear proteins. PMID:12371535
BRD-NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation. PMID:17934517
Results report that the double bromodomain proteins Brd2 and Brd3 associate preferentially in vivo with hyperacetylated chromatin along the entire lengths of transcribed genes. PMID:18406326