BOC Antibody

Code: CSB-PA866299ESR2HU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q9BWV1

Target Names

BOC

Alternative Names

BOC antibody; UNQ604/PRO1190Brother of CDO antibody; Protein BOC antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Brother of CDO protein (1-125AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA866299ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA866299ESR2HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

Gene References into Functions

we report the identification of missense BOC variants in HPE patients. Consistent with these alleles functioning as HPE modifiers, individual variant BOC proteins had either loss- or gain-of-function properties in cell-based SHH signaling assays. PMID:28677295
BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth. PMID:27871935
Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype PMID:28915250
Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID:20519495
Boc receptor is required for segregation of ipsilateral axons at the optic chiasm and, conversely, Boc expression in contralateral retinal ganglion cells prevents their axons from crossing the optic chiasm. PMID:20053908
CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID:12720294
Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. PMID:16647304
BOC, along with CDO, defines a new subfamily of the immunoglobulin superfamily that is conserved from Drosophila to man. BOC and CDO form a putative receptor complex that stimulates differentiation of myoblasts. PMID:11782431