BMP5 Antibody

Code: CSB-PA001026

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: WB, IHC, ELISA

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Target Background

Product Details

Uniprot NO.

P22003

Target Names

BMP5

Alternative Names

BMP 5 antibody; BMP-5 antibody; Bmp5 antibody; BMP5_HUMAN antibody; Bone morphogenetic protein 5 antibody; MGC34244 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human BMP-5.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, IHC, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Images

Western Blot analysis of HuvEC cells using BMP-5 Polyclonal Antibody
Western Blot analysis of VEC 293 A549 cells using BMP-5 Polyclonal Antibody

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Target Background

Function(From Uniprot)

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation.

Gene References into Functions

Suggest a significant role of miR-32/BMP5 axis in colorectal cancer tumorigenesis. PMID:30119170
findings suggested that BMP5 might be a potential prognostic biomarker or therapeutic target for patients with NSCLC PMID:25994008
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population. PMID:25030405
Data indicate significant association between the bone morphogenetic protein 5 (BMP5) microsatellite and knee osteoarthritis (OA) in women, but not in men. PMID:23186552
BMP5, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP5 signaling may play a pivotal role in disease development. PMID:24551273
BMP5 and BMP7, involved in cardiomyocyte differentiation defect PMID:24384427
CASP3 rs4862396, BMP5 rs3734444 and IRS2 rs7986346 may affect the survival in patients after androgen-deprivation therapy for prostate cancer PMID:22844442
BMP-5 is expressed in the tubuli of adult kidneys. Its decreased expression in nephrosclerosis along with its regenerative capabilities in HK-2 cells may point to a protective role in hypertensive nephrosclerosis. PMID:21319131
Taken together, BMP4 and BMP5 simultaneously inhibit the growth and promote migration and invasion of the same pancreatic cells and thus exhibit a biphasic role with both detrimental and beneficial functions in pancreatic cancer progression PMID:21704030
Variability in gene expression of BMP5 may be an important contributor to osteoarthritis genetic susceptibility PMID:20021689
The expression signals of BMP-5 mRNA in malignant schwannoma were relatively lower than in benign lesions PMID:11642720
BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal (HPL) ligament cells. PMID:15516325
BMP5 is expressed in normal synovial tissue and was decreased in osteoarthritis and rheumatoid arthritis. PMID:16542506
The differential allelic expression (DAE) of BMP5 in human mesenchymal tissues obtained from 16 donors undergoing joint replacement for treatment of osteoarthritis, was examined. PMID:17220169