BMP3 Antibody

Code: CSB-PA001013

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: WB, ELISA

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Target Background

Product Details

Uniprot NO.

P12645

Target Names

BMP3

Alternative Names

BMP-3 antibody; BMP-3A antibody; bmp3 antibody; BMP3_HUMAN antibody; BMP3A antibody; Bone morphogenetic protein 3 (osteogenic) antibody; Bone morphogenetic protein 3 antibody; Bone morphogenetic protein 3A antibody; Osteogenin antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human BMP-3A.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of HepG2 cells using BMP-3A Polyclonal Antibody
Western Blot analysis of NIH-3T3 cells using BMP-3A Polyclonal Antibody

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Target Background

Function(From Uniprot)

Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways.

Gene References into Functions

This study demonstrated that there was a significantly higher frequency of BMP3 methylated DNA in plasma in patients with polyps versus healthy controls with a sensitivity and specificity of 40 and 94%, respectively. PMID:29892846
BMP3 - the biomarker of a currently in-use multi-target stool DNA test was commonly expressed in tumor tissue specimens, independent of Fecal Immunochemical Test result. PMID:28044229
Methylation level in stool decreases dramatically following colorectal cancer resection PMID:24993691
Bone morphogenic protein 3 signaling in the regulation of osteogenesis. PMID:23127436
As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype. PMID:22303795
a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels PMID:21628466
Features supportive of positive selection in the BMP3 gene were found including the presence of an excess of nonsynonymous mutations in modern humans, and a significantly lower genetic diversity that deviates from neutrality PMID:20532035
Data suggest that promotor region methylation of the BMP3 gene may cause gastric carcinoma in Chinese people. PMID:20238409
These results demonstrate that BMP-3 stimulates mesenchymal stem cell proliferation via the TGF-beta/activin signaling pathway. PMID:20143330
The expression signals of BMP3 mRNA in malignant schwannoma were relatively lower than in benign lesions PMID:11642720
BMP-3 receptor specificity is controlled by the interaction of Lys-30 of BMP-3 with Glu-76 of ActRIIb PMID:17924656
BMP3 silencing is an early and frequent event in colorectal tumors progressing via the serrated and traditional pathways. PMID:18311777