BAZ1A Antibody

Code: CSB-PA140877

Rate （N/A）
Review （0）

Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,IHC

Send an Inquiry

Start an on-line Chat

Online ordering is currently available for U.S. customers only. For orders outside the U.S., please kindly submit an inquiry or start a chat with us.

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot NO.

Q9NRL2

Target Names

BAZ1A

Alternative Names

Acf1 antibody; ACF1; drosophila; homolog of antibody; ATP dependent chromatin remodelling protein antibody; ATP utilizing chromatin assembly and remodeling factor 1 antibody; ATP-dependent chromatin-remodeling protein antibody; ATP-utilizing chromatin assembly and remodeling factor 1 antibody; B930060C03 antibody; Baz1a antibody; BAZ1A_HUMAN antibody; BC065123 antibody; Bromodomain adjacent to zinc finger domain 1A antibody; Bromodomain adjacent to zinc finger domain protein 1A antibody; cbp146 antibody; CHRAC subunit ACF1 antibody; DKFZp586E0518 antibody; FLJ14383 antibody; Gtl5 antibody; hACF1 antibody; hWALp1 antibody; WALp1 antibody; WCRF180 antibody; Williams syndrome transcription factor related chromatin remodeling factor 180 antibody; Williams syndrome transcription factor-related chromatin-remodeling factor 180 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human BAZ1A

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA140877(BAZ1A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression.

Gene References into Functions

Results from the study on gene variability in early stage embryos identifies BAZ1A as a putative variability marker of the 8-cell embryo stage. PMID:26288249
Results from the study suggest that acute cocaine exposure increased Baz1a expression in nucleus accumbens while repeated cocaine exposure produced the opposite effect. Findings implicate BAZ1A in molecular and behavioral plasticity to cocaine and offer new insight into the pathophysiology of cocaine addiction. PMID:28412501
promotes recovery after DNA damage, in part by recruiting SMARCA5 to damaged chromatin PMID:29021563
Study reports de novo mutation in BAZ1A, in a patient with a syndromic form of intellectual disability (ID). This mutation affects the expression of genes involved in several biological pathways such as vitamin D regulation, Wnt signaling, and postsynaptic signaling. Data point to an important role for BAZ1A in neurodevelopment, and highlight a possible link for BAZ1A to ID. PMID:27328812
CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities. PMID:25533843
ISWI proteins Snf2H, Snf2L as well as Acf1 accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes. PMID:21738833
hACF1-containing factors are more generally involved in the DNA damage response. PMID:21745822
The ACF1 and its complexes play important roles in DNA double-strand breaks (DSBs) repair. PMID:21172662
The data support a model in which the human ACF anf yeast RSC remodeling enzymes move nucleosomes to new locations by a general sequence-independent mechanism. PMID:19450608
ACF1 alters the remodeling strategy of SNF2h PMID:16877760
Has a critical role in the transcriptional repression of specific nuclear hormone receptor-regulated genes. PMID:17519354