AZIN1 Antibody

Code: CSB-PA002484GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

O14977

Target Names

AZIN1

Alternative Names

Antizyme inhibitor 1 antibody; AZI antibody; Azin1 antibody; AZIN1_HUMAN antibody; OAZI antibody; OAZIN antibody; ODC1L antibody; Ornithine decarboxylase antizyme inhibitor antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human AZIN1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.

Gene References into Functions

Using high-resolution (1)H-NMR spectroscopy, we demonstrated that a long-looped quadruplex in the AZIN1 mRNA co-exists in salt-dependent equilibria with a hairpin structure. PMID:30063205
e in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer. PMID:28849733
AzI1 fulfils an essential regulatory function in polyamine homeostasis and cell proliferation. PMID:25813938
Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN). PMID:26305948
This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation. PMID:15670771
edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 PMID:23291631
minor allelic SNP variant in 12th exon of AZIN1 associated with slower rates of fibrosis progression favors expression of novel splice form, AZIN1 SV2, that inhibits expression of fibrogenic genes in hepatic stellate cells. PMID:21837750
AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function. PMID:21931692
SNP rs2679757 in the AZIN1 gene is associated with the risk of HBV-related liver cirrhosis in Chinese patients. PMID:21586232
Decreased ornithine decarboxylase is associated with prostate cancer. PMID:20215859