ATG4B Antibody

1. ATG4B expression was observed markedly upregulated by EWS-FLI1 overexpression, and silencing of ATG4B dramatically inhibits autophagy in Ewing sarcoma cells. PMID:28902354
2. study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B PMID:28835545
3. ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 PMID:28287329
4. O-GlcNAcylation of ATG4B regulates autophagy activation by increasing its proteolytic activity under metabolic stress condition PMID:27527864
5. these results demonstrate a novel association of ATG4B positive expression with HER2 positive breast cancers PMID:27556700
6. Knockdown of ATG4B had only a minor effect on AMPK activation and G1 phase arrest in liver kinase B1-deficient or AMPK-inhibited cancer cells. PMID:29169176
7. Our work describes an MST4-ATG4B signaling axis that influences glioblastoma autophagy and malignancy PMID:29232556
8. Data show that ULK1, a protein kinase activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316. PMID:28821708
9. Reporter assay showed that HSF1 increased the transcriptional activity of ATG4B gene promoter, and chromatin immunoprecipitation assay verified that HSF1 bound to the site (-1429 to -1417) in ATG4B gene promoter region. PMID:28889000
10. The structure and regulatory machinery of Atg4b [review] PMID:28253956
11. MIRlet-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of pre-eclampsia. PMID:27770612
12. Results demonstrated that upregulation of miR-34a by transfection or demethylation resulted in the enhanced apoptosis and drug sensitivity in prostate cancer cells. ATG4B, directly regulated by miR-34a through AMPK/mTOR, was involved in this process. PMID:26499184
13. Purified ATG4B protein interact with LC3B in vitro. PMID:25652856
14. ATG4B independently plays a role as a positive regulator on tumor proliferation and a negative regulator on autophagy in colorectal cancer cells. PMID:24991826
15. This study identifies ATG4B as a potential biomarker for predicting therapeutic response in treatment-naive chronic myeloid leukemia stem/progenitor cells and uncovers ATG4B as a possible drug target in these cells. PMID:24755409
16. The actions of ATG4 family members (particularly ATG4B) are required for the control of autophagosome fusion with late, degradative compartments in differentiating human erythroblasts. PMID:23508006
17. HsAtg4B negatively regulates the localization of LC3 to a membrane compartment by delipidation PMID:15187094
18. analysis of specificity and catalysis of HsAtg4B PMID:16183633
19. crystal structure of human Atg4b by X-ray crystallography at 2.0 A resolution, and show that Atg4b is a cysteine protease whose active catalytic triad site consists of Cys74, His280 and Asp278 PMID:16325851
20. Murine Atg8L/Apg8L modification is mediated by human Atg4B. PMID:16704426
21. The crystal structures of catalytically inert human Atg4B in complex with processed and unprocessed forms of LC3 showed that, on LC3 binding, the regulatory loop and the N-terminal tail of HsAtg4B undergo large conformational changes. PMID:19322194

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HGNC: 20790

UNIGENE: Hs.283610

KEGG: hsa:23192

STRING: 9606.ENSP00000384259

OMIM: 611338