APBB1IP Antibody

Code: CSB-PA030130

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: WB, ELISA

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Target Background

Product Details

Uniprot NO.

Q7Z5R6

Target Names

APBB1IP

Alternative Names

APBB1IP antibody; PREL1 antibody; RARP1 antibody; RIAMAmyloid beta A4 precursor protein-binding family B member 1-interacting protein antibody; APBB1-interacting protein 1 antibody; Proline-rich EVH1 ligand 1 antibody; PREL-1 antibody; Proline-rich protein 73 antibody; Rap1-GTP-interacting adapter molecule antibody; RIAM antibody; Retinoic acid-responsive proline-rich protein 1 antibody; RARP-1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human RIAM.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of A549 cells using RIAM Polyclonal Antibody

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

Gene References into Functions

Authors provide an overview of the structure and interactions of RIAM and discuss the implications of RIAM functions in innate and adaptive immunity and cancer. [Review] PMID:28831022
Disruption of the RIAM/lamellipodin-integrin-talin complex markedly impairs cell migration. PMID:26419705
RIAM is a critical component of the phagocytosis machinery downstream of Rap1 and mediates its function by recruiting talin to the phagocytic complement receptors. PMID:23420480
integrin-triggered, RIAM-dependent MEK activation represents a key feedback event required for efficient focal adhesion disassembly. PMID:22946047
RIAM was recruited to the lymphocyte plasma membrane through its Ras association and pleckstrin homology domains, both of which were required for lymphocyte adhesion. PMID:23045549
RIAM might contribute to the dissemination of melanoma cells. PMID:21454517
by regulating the localization of PLC-gamma1, RIAM plays a central role in TCR signaling and the transcription of target genes. PMID:19952372
all-trans-retinoic acid-inducible RARP1 selectively affects signal transduction and may contribute to myeloid and megakaryocytic differentiation.(RARP1) PMID:14530287
Data pinpoint PREL1 as the first direct link between Ras signalling and cytoskeletal remodelling via Ena/VASP proteins during cell migration and spreading. PMID:15642358
a minimized 50-residue Rap-RIAM module containing the talin binding site of RIAM joined to the membrane-targeting sequence of Rap1A. This minimized Rap-RIAM module was sufficient to target talin to the plasma membrane and to mediate integrin activation PMID:19098287