ANTXR2 Antibody

1. A decreased CMG2 expression is a negative prognostic factor for soft tissue sarcoma patients. PMID:29215551
2. Results identified Gly116Val mutation in ANTXR2 associated with hyaline fibromatosis syndrome. PMID:28103792
3. Stability of domain 4 of the anthrax toxin protective antigen and the effect of the VWA domain of CMG2 on stability PMID:27874231
4. study examines 4 cases with clinical features of hyaline fibromatosis syndrome; identified a previously unreported splice junction mutation (c.946-2A-->G in intron 11) and a recurrent founder mutation ( c.1074delT) PMID:27174544
5. This study reports a novel association between ANTXR2 and ankylosing spondylitis in the Han Chinese. PMID:26728147
6. Case Report: systemic hyalinosis with a heterozygous mutation in CMG2. PMID:26885603
7. The association between ANTXR2 rs4333130 and ankylosing spondylitis was independent of HLA-B27 status. Clinical disease severity scores (BASDAI and BASFI) and pain score were higher in ANTXR2 rs4333130 CT genotype. PMID:26590821
8. Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation PMID:26805886
9. Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression PMID:26703731
10. miR-124 might induce autophagy to participate in AS by targeting ANTXR2, which might be implicated in pathological process of AS. PMID:25736362
11. The disulfide bond Cys255-Cys279 in the immunoglobulin-like domain of ANTXR2 is required for membrane insertion of anthrax protective antigen pore. PMID:26107617
12. CMG2 glycosylation provides a buffer towards genetic variation by promoting folding of the protein in the ER lumen. PMID:25781883
13. Results show that CMG2 has been shown to be able to regulate the proliferation and tubule formation of endothelial cells, but not the migration. PMID:24993339
14. Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene. PMID:25169729
15. data suggested that cellular cholesterol regulated ANTXR2-dependent activation of MMP-2 via ERK1/2 phosphorylation in neuroglioma U251 cell. PMID:24924630
16. Fused the ANTXR2 ectodomain to the C-terminus of bacterial Trigger Factor (TF), and the fusion protein was overly expressed as a dominant soluble protein in E coli. PMID:24380801
17. Silencing CMG2 using targeted siRNAs provided almost complete protection against anthrax lethal toxin-induced cytotoxicity and death in murine and human macrophages. PMID:24742682
18. Loss of CMG2 expression is associated with breast cancer progression. PMID:24667935
19. A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation PMID:24641616
20. Investigated the kinetics of binding as a function of pH to the full-length monomeric anthrax protective antigen(PA)and to two variants to CMG2. Results suggest that for the full-length PA, low pH increases the binding affinity. PMID:22855243
21. 2 novel ANTXR2 mutations were identified in patients with hyaline fibromatosis syndrome PMID:22383261
22. ANTXR2 and IL-1R2 polymorphisms are not associated with ankylosing spondylitis in Chinese Han population. PMID:20652271
23. results reveal extensive diversity in cell lethality dependent on anthrax toxin PA-mediated toxin binding and uptake, and identify individual differences in CMG2 expression level as a determinant of this diversity PMID:22315420
24. ANTXR2 might not be a susceptibility gene of Ankylosing Spondylitis in Chinese Han. PMID:22118297
25. Missense mutations in the extracellular von Willebrand domain of CMG2 lead to protein folding defects. PMID:21328543
26. the molecular basis (spectrum of ANTXR2 mutations) of infantile systemic hyalinosis and juvenile hyaline fibromatosis in two unrelated Egyptian families PMID:20331448
27. Divalent metal ion coordination by residue T118 of anthrax toxin receptor 2 is not essential for protective antigen binding. PMID:17183731
28. Cytoplasmic delivery of lethal factor by anthrax toxin receptor 2 was mediated by cathepsin B. PMID:19858192
29. identification and characterization of juvenile hyaline fibromatosis and infantile systemic hyalinosis disease-causing mutations in the capillary morphogenesis factor-2 gene PMID:12973667
30. identification of 15 different mutations in the gene encoding capillary morphogenesis protein 2 in 17 families with juvenile hyaline fibromatosis or infantile systemic hyalinosis PMID:14508707
31. structures provide a template to begin probing the high-affinity capillary morphogenesis protein 2-protective antigen interaction and may facilitate understanding of toxin assembly/internalization PMID:15079089
32. crystal structure of the complex with anthrax toxin PMID:15243628
33. Molecular dynamics simulations explain the great strength that the protective antigen-capillary morphogenesis gene 2 complex achieves through extraordinary coordination of a divalent cation. PMID:16473908
34. Results suggest that, in vivo, slow folding, rather than misfolding, is responsible for ER retention, and that systemic hyalinosis can be qualified as a conformational disease. PMID:19191226

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HGNC: 21732

UNIGENE: Hs.162963

KEGG: hsa:118429

STRING: 9606.ENSP00000306185

OMIM: 228600