AKAP11 Antibody

Code: CSB-PA006794

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: IHC, IF, ELISA

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Target Background

Product Details

Uniprot NO.

Q9UKA4

Target Names

AKAP11

Alternative Names

AKAP11 antibody; AKAP220 antibody; KIAA0629 antibody; A-kinase anchor protein 11 antibody; AKAP-11 antibody; A-kinase anchor protein 220 kDa antibody; AKAP 220 antibody; hAKAP220 antibody; Protein kinase A-anchoring protein 11 antibody; PRKA11 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of Human AKAP 220.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

IHC, IF, ELISA

Protocols

Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Gene References into Functions

PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. PMID:25188285
Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3beta to A-kinase Anchoring Protein 220. PMID:26088133
AKAP220 protein organizes signaling elements that impact cell migration. PMID:21890631
binds to glycogen synthase kinase-3beta (GSK-3beta) and mediates protein kinase A-dependent inhibition of GSK-3beta PMID:12147701

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Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.

Protein Families

AKAP110 family

Tissue Specificity

Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.

Database Links

HGNC: 369

UNIGENE: Hs.105105

KEGG: hsa:11215

STRING: 9606.ENSP00000025301

OMIM: 604696

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