ADGRB2 Antibody

Code: CSB-PA523985LA01HU

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US$83

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Species Reactivity: Human, Rat

Raised in: Rabbit

Application: ELISA, WB, IF

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Target Background

Product Details

Uniprot NO.

O60241

Target Names

ADGRB2

Alternative Names

ADGRB2 antibody; BAI2Adhesion G protein-coupled receptor B2 antibody; Brain-specific angiogenesis inhibitor 2 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Adhesion G protein-coupled receptor B2 protein (1371-1545AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: Rat brain tissue
All lanes: ADGRB2 antibody at 3.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 173, 172, 170 kDa
Observed band size: 173 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA523985LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Target Background

Function(From Uniprot)

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition.

Gene References into Functions

These studies provide new insights into the signaling capabilities of the adhesion GPCR BAI2/ADGRB2 and shed light on how an apparent gain-of-function mutation to the receptor's C-terminus may lead to human disease. PMID:28891236
This is the first study reporting BAI2 as an interaction partner of GIP. PMID:21787750
BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway PMID:20367554
involvement of BAI2 in the ischemia-induced brain angiogenesis PMID:12218411