ADCY3 Antibody

Code: CSB-PA241921

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

O60266

Target Names

ADCY3

Alternative Names

AC-III antibody; AC3 antibody; ADCY3 antibody; ADCY3_HUMAN antibody; adenylate cyclase 3 antibody; Adenylate cyclase antibody; Adenylate cyclase type 3 antibody; Adenylate cyclase type III antibody; Adenylyl cyclase 3 antibody; ATP pyrophosphate lyase antibody; ATP pyrophosphate-lyase 3 antibody; olfactive type antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human ADCY3

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA241921(ADCY3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA241921(ADCY3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, human fetal brain tissue, Primary antibody: CSB-PA241921(ADCY3 Antibody) at dilution 1/312.5, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes

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Target Background

Function(From Uniprot)

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.

Gene References into Functions

This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet. PMID:29921800
In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops. PMID:28122017
Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase PMID:25431134
The association signal of height-adjusted BMI at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. PMID:25044758
Data demonstrate that the expression of ADCY3 is regulated through an epigenetic mechanism. PMID:24113161
endoplasmic reticulum calcium store operated cAMP production occurred preferentially via the adenylate cyclase 3 PMID:22681560
Genetically mutated serine(1076) of adenylyl cyclase III (ACIII) affects neither the cilial localization nor expression level of ACIII in olfactory sensory neurons. PMID:23077041
This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder. PMID:21042317
Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. PMID:21079816
identified AC3as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation PMID:12623444
expression of nodular ADCY6, but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules PMID:12782409
Establishment of the mature glomerular array in transgenic mice requires adenylyl cyclase 3, a key component of the odorant receptor-mediated cyclic AMP-dependent signaling cascade. PMID:17581954
This the first evidence that AC3 polymorphisms confer the risk susceptibility to obesity in Swedish men with and without type 2 diabetes. PMID:17895882
These results suggest that the length of primary cilia is controlled, at least in part, by the adenylate cyclase III-cAMP signaling pathway. PMID:19576885

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus.

Protein Families

Adenylyl cyclase class-4/guanylyl cyclase family

Tissue Specificity

Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis.

Database Links

HGNC: 234

UNIGENE: Hs.467898

KEGG: hsa:109

STRING: 9606.ENSP00000260600

OMIM: 600291

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