ACOT8 Antibody, FITC conjugated

Code: CSB-PA001170LC01HU

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Size:

50μl100μl

US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

O14734

Target Names

ACOT8

Alternative Names

ACOT8 antibody; ACTEIII antibody; PTE1 antibody; Acyl-coenzyme A thioesterase 8 antibody; Acyl-CoA thioesterase 8 antibody; EC 3.1.2.1 antibody; EC 3.1.2.11 antibody; EC 3.1.2.2 antibody; EC 3.1.2.3 antibody; EC 3.1.2.5 antibody; Choloyl-coenzyme A thioesterase antibody; EC 3.1.2.27 antibody; HIV-Nef-associated acyl-CoA thioesterase antibody; Peroxisomal acyl-CoA thioesterase 2 antibody; PTE-2 antibody; Peroxisomal acyl-coenzyme A thioester hydrolase 1 antibody; PTE-1 antibody; Peroxisomal long-chain acyl-CoA thioesterase 1 antibody; Thioesterase II antibody; hACTE-III antibody; hACTEIII antibody; hTE antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Acyl-coenzyme A thioesterase 8 protein (1-200AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-4 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation.; (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression.

Gene References into Functions

In summary, lipolytic enzyme ACOT8 is frequently upregulated in HCC clinical specimens. More importantly, ACOT8 silencing leads to inhibition of cell growth in HCC in vitro. PMID:24788990
Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma. PMID:23540296
ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids PMID:16141203
SREBP2 modulates brain palmitoyl-coa hydrolase gene transcription. PMID:16335799
An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol. PMID:17624024