ABCB8 Antibody

Code: CSB-PA868325ESR1HU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Human, Mouse

Raised in: Rabbit

Application: ELISA, WB, IHC

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Target Background

Product Details

Uniprot NO.

Q9NUT2

Target Names

ABCB8

Alternative Names

ABCB8; MABC1; MITOSUR; Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial ATP-binding cassette 1; M-ABC1; Mitochondrial sulfonylurea-receptor; MITOSUR

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human ATP-binding cassette sub-family B member 8, mitochondrial protein (486-735AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: ABCB8 antibody at 2.02 μg/ml
+ Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 80, 79, 76, 69, 60 kDa
Observed band size: 80, 55 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA868325ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA868325ESR1HU at dilution of 1:100

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Target Background

Function(From Uniprot)

ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes.

Gene References into Functions

ABCB8 confers resistance through the protection of mitochondrial DNA from doxorubicin-induced DNA damage in a melanoma cell line. PMID:19147539
mutations in ABCB8 and ABCB10 is not associated with acute myeloid leukemia. PMID:19151771

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Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein.

Protein Families

ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 49

UNIGENE: Hs.647118

KEGG: hsa:11194

STRING: 9606.ENSP00000351717