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Recombinant Macaca fascicularis Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3), partial (Active)

Recombinant Macaca fascicularis Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3), partial (Active)

CSB-MP4278MOV

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Size:

20ug100ug1mg

US$138

Quantity:

Express system: Mammalian cell

Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Tag Info: N-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Purity

Greater than 95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Activity

Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ENPP3 at 2 μg/mL can bind Anti-ENPP3 recombinant antibody (CSB-RA007681MA1HU), the EC₅₀ is 3.313-4.724 ng/mL.

Target Names

ENPP3

Uniprot NO.

A0A2K5TKP4

Molecular Characterization

Species

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Source

Mammalian cell

Expression Region

46-874aa

Target Protein Sequence

RKLEKQGSCRKKCFDASFRGLENCRCDVACEDRGDCCWDFEDTCVESTRIWTCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSEEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNRSVPYEERISTLLKWLDLPKAERPSFYTMYFEEPDSSGHASGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFYMYEGPAPRIRALNVPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDPQWLAVGSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTRGSLNHLLKVPFYKPSHAEEVSKFSVCGFANPLPTDNLSCLCPHLQNSIQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDNCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADENITHGFLYPPAINRTSDSQYDALIMSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPEEITKHIANTDIPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERLTAHIARVRDVELLTGLDFYQDKAQPVSEILQLKTYLPTFETTI

Mol. Weight

98.7 kDa

Protein Length

Partial

Tag Info

N-terminal 10xHis-tagged

Buffer

Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8

Storage

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Shelf Life

The shelf life is related to many factors, storage state, storage temperature and the stability of the product itself. Generally, the shelf life of lyophilized form is 6 months at -20°C/-80°C from the date of receipt.

Troubleshooting and FAQs

Protein FAQs

Datasheet & COA

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Images

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ENPP3 at 2 μg/ml can bind Anti-ENPP3 recombinant antibody (CSB-RA007681MA1HU), the EC₅₀ is 3.313-4.724 ng/mL.

Description

This Recombinant Macaca fascicularis ENPP3 was produced in mammalian cell, where the gene sequence encoding Macaca fascicularis ENPP3 (46-874aa) was expressed with the N-terminal 10xHis tag. The purity of this ENPP3 protein was greater than 95% by SDS-PAGE. The activity was measured by its binding ability in a functional ELISA.

ENPP3 gene encodes a type II transmembrane protein, which is a multifunctional extracellular nucleotide hydrolase whose main function is to metabolize extracellular nucleotides, including ATP, GTP, UTP and CTP. Restricts mast cell and basophil responses by eliminating extracellular ATP during inflammation and in the chronic phase of allergic responses. ATP, acting as a signaling molecule, activates basophils and mast cells and induces the release of inflammatory cytokines. ENPP3 metabolizes extracellular ATP in the lumen of the small intestine, preventing ATP-induced apoptosis of intestinal plasmacytoid dendritic cells, and ENPP3 also has alkaline phosphodiesterase activity.