IL1F10 Monoclonal Antibody

Code: CSB-MA8378691A0m

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Size:

50μg100μg

US$210

Quantity:

Species Reactivity: Human

Raised in: mouse

Application: ELISA,IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q8WWZ1

Target Names

IL1F10

Alternative Names

family of interleukin 1-theta antibody; FIL1 theta antibody; FIL1T antibody; FKSG75 antibody; IL 38 antibody; IL-1 theta antibody; IL-1F10 (canonical form IL-1F10a) antibody; IL-1F10 antibody; IL-1HY2 antibody; IL1 theta antibody; IL1F10 antibody; IL1FA_HUMAN antibody; IL1HY2 antibody; Interleukin 1 family member 10 (theta) antibody; Interleukin 1 receptor antagonist FKSG75 antibody; Interleukin 1 receptor antagonist homolog 2 antibody; Interleukin 1 receptor antagonist like FIL1 theta antibody; Interleukin-1 family member 10 antibody; Interleukin-1 HY2 antibody; Interleukin-1 theta antibody; interleukin-38 antibody

Raised in

mouse

Species Reactivity

Human

Immunogen

Recombinant Human IL1F10 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

monoclonal

Isotype

IgG1

Clone No.

2A2B3

Purification Method

>95%,protein G purifed

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:500

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemical of paraffin-embedded Human Colon cancer tissue using CSB-MA8378691A0m at dilution of 1:200.
Immunohistochemical of paraffin-embedded Human live cancer tissue using CSB-MA8378691A0m at dilution of 1:200.
Immunohistochemical of paraffin-embedded Human spleen tissue using CSB-MA8378691A0m at dilution of 1:200.

Description

The product CSB-MA8378691A0m is an IL1F10 mouse monoclonal antibody that specifically reacts with human IL1F10 protein. The immunogen used to generate this IL1F10 monoclonal antibody is the recombinant human IL1F10 protein. The purity of this IL1F10 antibody is greater than 95% using the protein G purification. This IL1F10 monoclonal antibody has been shown to be useful to detect the IL1F10 protein in ELISA and IHC.

IL1F10 is a cytokine, a small protein that plays a role in the regulation of immune responses and inflammation. It mainly modulates the immune system and protects the body against infections. IL1F10 has been shown to stimulate the production of other cytokines, such as IL-6 and TNF-α, and to activate the NF-κB signaling pathway, which plays a key role in the regulation of immune responses.

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Target Background

Function(From Uniprot)

Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.

Gene References into Functions

The serum level of IL-38 in the children in the acute phase of Kawasaki disease was significantly lower than that in the healthy control group PMID:30022755
IL-38 may play an important role in acute and/or chronic inflammation in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis. PMID:28942884
IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts. PMID:28288964
this clinical study demonstrates the elevation of anti-inflammatory cytokine IL-38 and the decrement of CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg in childhood asthma. The negative correlation of IL-38 and Treg lymphocytes may imply a negative feedback of the two anti-inflammatory factors in asthma. PMID:27438823
this study shows that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production PMID:27723569
Higher serum IL-38 levels before treatment indicate a greater probability of viral response to telbivudine treatment in chronic hepatitis B. PMID:27182162
results indicate that circulating IL-38 is a potentially novel biomarker for patients with ST-segment elevation myocardial infarction PMID:26819499
Data suggest that IL-38 may be protective in SLE. A strong association between IL-38 and SLE severity suggests that IL-38 expression is driven by processes linked to SLE pathogenesis. PMID:26314375
rs6759676, closest gene locus IL1F10 is associated with increased circulating levels of IL-1 receptor antagonist, a protective factor in development of insulin resistance. PMID:24969107
The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis. PMID:22312160
These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID:22315422