Abbreviation
Recombinant Human IL19 protein, partial (Active)
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU/μg as determined by LAL method.
Activity
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human IL-20Rα and human IL-20Rβ co-transfected murine BaF3 pro-B cells is less than 1.5 ng/ml, corresponding to a specific activity of >6.7x105 IU/mg.
Alternative Names
IL 10C; IL 19; IL-19; Il19; IL19_HUMAN; Interleukin 19; Interleukin-19; MDA1; Melanoma differentiation-associated protein-like protein; NG.1; ZMDA1
Species
Homo sapiens (Human)
Expression Region
25-177aa
Target Protein Sequence
LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL AWINKNHEVM SSA
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Partial of AF192498
Tag Info
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Buffer
Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Lead Time
5-10 business days
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Datasheet & COA
Please contact us to get it.
Description
IL-19 signals through the IL-20Rα/IL-20Rβ heterodimer to modulate epithelial and immune cell responses, making precise recombinant forms of this cytokine essential for dissecting its role in inflammatory and autoimmune pathways. This tag-free human IL-19 (residues 25–177) demonstrates strong signaling potency, with an ED50 below 1.5 ng/mL and a specific activity exceeding 6.7 × 10⁵ IU/mg in a proliferation assay using IL-20Rα/IL-20Rβ co-transfected BaF3 cells — data that supports use in cell-based functional assays such as proliferation, differentiation, and STAT3 phosphorylation studies downstream of JAK/STAT activation. Endotoxin levels below 1.0 EU/μg minimize LPS-driven artifacts, providing a suitable basis for sensitive immune cell experiments and in vivo inflammation models where confounding innate immune activation must be controlled. Purity exceeding 95% by SDS-PAGE further aligns with standards expected in antibody validation workflows, ELISA development, and use as a reference standard in cytokine detection assays.
