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Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit

Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit

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Code: CSB-E04669r

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Size:

96T,5×96T,10×96T

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Quantity:

Sample Types: serum, plasma, tissue homogenates

Detect Range: 0.156 ng/ml-10 ng/ml

Sensitivity: 0.039 ng/ml

Trial Size:

24T ELISA Kit Trial Size (Only USD$150/ kit)
* Sample kit cost can be deducted as a $30 credit for each 96-assay kit of the same analyte and brand you subsequently purchase within six months until depleted. More details >>

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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Alternative Names

Ccl20 ELISA Kit; Scya20 ELISA Kit; St38C-C motif chemokine 20 ELISA Kit; Beta-chemokine exodus-1 ELISA Kit; CC chemokine LARC ELISA Kit; CC chemokine ST38 ELISA Kit; Liver and activation-regulated chemokine ELISA Kit; Macrophage inflammatory protein 3 alpha ELISA Kit; MIP-3-alpha ELISA Kit; Small-inducible cytokine A20 ELISA Kit

Abbreviation

CCL20

Uniprot NO.

P97884

Species

Rattus norvegicus (Rat)

Sample Type

serum, plasma, tissue homogenates

Detection Range

0.156 ng/ml-10 ng/ml

Sensitivity

0.039 ng/ml

Assay Time

1-5h

Sample Loading Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Immunology

Assay Principle

quantitative
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Measurement

Sandwich

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Troubleshooting and FAQs

ELISA kit FAQs

ELISA Data Analysis

ELISA Standard Curve & Curve Expert software

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.

Gene References into Functions

The results suggest a potential mechanism for the recruitment of IL-17-producing cells to degenerated intervertebral discs via a CCL20/CCR6 axis in vivo. PMID:26704184
Data show that systemic inflammatory reaction to raumatic brain injury starts before local brain response and suggest that CCL20 might play a role in promoting neuronal injury and central nervous system inflammation in response to mild TBI. PMID:22040257
the role of TGF beta 1 in high glucose-induced MIP-3 alpha expression PMID:17664181
These findings suggest that MIP-3alpha/Ccl20 plays a pivotal role in inflammatory cascades in ischemic brains, and may be a novel therapeutic target for cerebral ischemia. PMID:19428685