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Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Gene References into Functions
This study demonstrated the amelioration of MOG35-55 peptide-induced active EAE in CD30 KO mice. CD30 was expressed limitedly on CD4 T cells at the induction phase of experimental autoimmune encephalomyelitis.PMID:26857493
Data indicate that CD30L/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE).PMID:25533628
role in the maintenance and activation of IL-17A-producing gammadelta T cellsPMID:23549449
These results suggest that CD30 signaling plays an important role in the activation of IL-17A-producing Vgamma1(-) Vgamma4(-) gammadelta T cells bearing Vgamma6 at an early stage of BCG infection.PMID:23918785
Interference of the CD30-CD30L pathway reduces atherosclerosis development.PMID:23087358
CD30L/CD30 pathway acts as an accelerator of enteritis in a murine disease modelPMID:22451116
role of CD30L/CD30 interactions in allergic rhinitis; results suggest that CD30L plays an important role in allergic rhinitisPMID:21739429
Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.PMID:21788408
Studies demonstrate that CD30L/CD30 signaling executed by the T-T cell interaction plays a critical role in Th17 cell differentiation.PMID:20639486
CD30 can signal in a completely TCR-independent fashion to induce IL-13 production by effector T cells.PMID:12193714
Immunity to CD30 could play a role in Marek disease lymphoma regression.PMID:15356338
Deficiencies in OX40 and CD30 signals were additive, secondary Ab responses were ablated.OX40/CD30 double-knockout OTII transgenic T cells fail to survive compared with normal T cells when cocultured with CD4(+)CD3(-) cells in vitro.PMID:15778343
CD30 plays an important role in the generation of long-lived memory CD8+ T cells, at least partly by triggering homing receptors for T(central memory) cells.PMID:16177108
early CD30 signaling is critical for regulatory T cells-mediated acute graft-versus-host disease protection after major MHC-mismatch bone marrow transplantationPMID:17068147
These results indicate that CD30 is a regulator of T(h)2 responses in the effector-memory phase and a regulator of IL-13 production in memory cells in the lung.PMID:18089617
CD30L/CD30 signaling is involved in development of both OXA- and TNBS-induced colitis. Modulation of CD30L/CD30 signaling by mAb could be a novel biologic therapy for inflammatory bowel diseases.PMID:18242212
CD30 and OX40 signals are both required for the survival but not commitment of CD4 T helper type 1 (Th1) cells.PMID:18292503
Signaling executed by CD30positive T cell interaction with CD30Lpositive T cells plays a critical role in amplification of T helper type (Th)1 responses that able to produce interferon-gamma against Mycobacterium bovis bacillus Calmette-Guerin infection.PMID:18941223
ko mice exhibite delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes after infection with erogenic Mycobacterium aviumPMID:19250702
CD30 signals from lymphoid tissue inducer cells were a primitive mechanism to recruit and prime CD4 T cellsPMID:19342654
Data demonstrate that the crucial role of CD30 signaling in the development of acute asthma may be taken over by other costimulatory molecules like OX40 after long-term exposure to the antigen.PMID:19544310
Following infection with murine cytomegalovirus, CD30 is necessary for preserving the lymphoid microenvironment by enhancing the protective function of NK cells.PMID:19731363
signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria.PMID:19786532
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Subcellular Location
Cell membrane; Single-pass type I membrane protein.