ZC3HAV1 Antibody

Code: CSB-PA767190XA01HU

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Homo sapiens (Human)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q7Z2W4

Target Names

ZC3HAV1

Alternative Names

ADP ribosyltransferase diphtheria toxin like 13 antibody; ARTD13 antibody; FLB6421 antibody; PARP13 antibody; ZAP antibody; ZC3H2 antibody; ZC3HAV 1 antibody; Zc3hav1 antibody; ZC3HDC 2 antibody; ZC3HDC2 antibody; ZCCHV antibody; ZCCHV_HUMAN antibody; Zinc finger antiviral protein antibody; Zinc finger CCCH domain containing protein 2 antibody; Zinc finger CCCH domain-containing antiviral protein 1 antibody; Zinc finger CCCH domain-containing protein 2 antibody; Zinc finger CCCH type antiviral 1 antibody; Zinc finger CCCH type antiviral protein 1 antibody; Zinc finger CCCH-type antiviral protein 1 antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) ZC3HAV1 protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

Gene References into Functions

results indicate that low ZAP expression is common in hepatocellular carcinoma (HCC), is correlated with the progression of HCC and with a poorer prognosis for HCC patients, and plays an important role in HCC carcinogenesis PMID:30196292
In response to DNA damage, activated and auto-poly-ADP-ribosylated PARP1 dissociates from HSF1-PARP13, and redistributes to DNA lesions and DNA damage-inducible gene loci. PMID:29158484
The results indicate that an equilibrium between ZAP and enterovirus 3C protease controls viral infection. PMID:29182509
Herpes simplex virus 1 UL41 was shown for the first time to evade the antiviral function of human ZAP via its RNase activity. PMID:26625984
The association of the ZAP ribonucleoprotein particle with many interferon-stimulated gene products indicates it may be a key player in the interferon response. PMID:26001115
Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression. PMID:26129669
PARP13 regulates RNA in stress and disease. [review] PMID:25851173
PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript. PMID:25382312
results show that PARP13 lacks the structural requirements for ADP-ribosyltransferase activity PMID:25635049
Contrary to previous assumptions, these results indicate an essential function of the PARP-like domain in hZAP-L's antiviral activity. PMID:24457973
Data suggest that two isoforms of ZAP (ZAP-long and -short) inhibit replication of hepatitis B virus and replication of viral DNA in hepatocytes through posttranscriptional down-regulation of viral RNA. PMID:23853601
S-farnesylation is crucial for targeting the long-isoform of ZAP to endolysosomes and enhancing the antiviral activity of this immune effector. PMID:23776219
ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency PMID:22951821
The Thr851Ile SNP of ZC3HAV1 is significantly associated with susceptibility to multiple sclerosis PMID:22319148
Results indicate that ZAP inhibits HIV-1 by recruiting both the 5' and 3' mRNA degradation machinery to specifically promote the degradation of multiply spliced HIV-1 mRNAs. PMID:21876179
shorter isoform (ZAPS)stimulates interferon responses mediated by the RNA helicase RIG-I PMID:21102435
ZAP is a direct target gene of IRF3 action in cellular antiviral respon PMID:20048147
These findings suggest that ZAP recruits the cellular RNA degradation machinery for the degradation of viral RNA. PMID:20451500
Our findings demonstrate that ZAP can synergize with another IFN-induced factor(s) for maximal alphaviruses antiviral activity and that ZAP's intrinsic antiviral activity on virion production and cell survival can have cell-type-specific outcomes. PMID:17928353
This study finds that human ZAP encodes a potent antiviral activity against alphaviruses. PMID:18225958
ZAP, TIPARP and FLJ22693 proteins with TPH, WW and PARP-like domains constitute the TIPARP family. PMID:12851707