Ywhaz Antibody

1. DEX can increase IOP in mouse eyes and concurrently downregulate 14-3-3 zeta protein expression in mouse TM PMID:28494163
2. These results demonstrate that miR-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3sigma expression, and suggest that miR-146a may be a potential target for asthma therapy. PMID:29101850
3. When taken together these findings demonstrate novel roles of 14-3-3zeta in the regulation of glucose homeostasis and suggest that modulating 14-3-3zeta levels in intestinal L cells may have beneficial metabolic effects through GLP-1-dependent mechanisms. PMID:27167773
4. Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding. PMID:27401462
5. PKCdelta-mediated phosphorylation of 14-3-3zeta contributes to the nuclear retention of FOXO1, even when FOXO1 is phosphorylated as under non-stress conditions PMID:26363783
6. 14-3-3zeta deficient mice in the BALB/c background display behavioral and anatomical defects associated with Schizophrenia-like disorder. PMID:26207352
7. Ywhaz coordinates adipogenesis in visceral fat. PMID:26220403
8. An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1. PMID:25645340
9. In the majority of NAFLD treatment groups and time points the most stable gene was YWHAZ. PMID:22583519
10. By preventing the inactivation of cofilin, metabolic stress-induced degradation of 14-3-3zeta promotes the conversion of blood monocytes into a hypermigratory, proatherogenic phenotype. PMID:24812321
11. 14-3-3zeta KO mice displayed enhanced locomotor hyperactivity induced by the dopamine (DA) releaser amphetamine. Consistent with 14-3-3zeta having a role in DA signalling, we found increased levels of DA in the striatum of 14-3-3zeta KO mice. PMID:24301645
12. The activated serine/threonine kinase Akt/protein kinase B phosphorylated BTK on two sites prior to 14-3-3 zeta binding. PMID:23754751
13. studies demonstrate that increased 14-3-3zeta levels protect against ER stress and seizure-damage despite down-regulation of the unfolded protein response PMID:23359526
14. Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways. PMID:23355742
15. 14-3-3 zeta as the only prognosticator of local recurrence-free survival (LRFS) and also an independently predicted factor of disease-specific survival (DSS). PMID:21322651
16. results suggest that 14-3-3zeta, a novel direct binding partner of the L1ICD, promotes L1 phosphorylation by CKII in the central nervous system, and regulates neurite outgrowth, an important biological process triggered by L1 PMID:20976158
17. Mutation of the 14-3-3 zeta phosphorylation sites in Smad3 markedly reduced the 14-3-3-zeta-mediated inhibition of TGF-beta1-induced p15 promoter-reporter activity & cell cycle arrest in mammary epithelial cells. PMID:20082218
18. an essential role of 14-3-3zeta as a mediator of the proerythroid differentiation actions of miR-451 PMID:20679397
19. in miR-144/451(-/-) erythroblasts, 14-3-3zeta accumulates, causing partial relocalization of FoxO3 from nucleus to cytoplasm with dampening of its transcriptional prog PMID:20679398
20. 14-3-3zeta controls CCTalpha nuclear import in response to calcium signals, thereby regulating mammalian phospholipid synthesis. PMID:20007511
21. 14-3-3 binds to phosphorylated Raf-1, blocking Raf-1 recruitment to the plasma membrane and preventing its activation PMID:12801936
22. 14-3-3zeta has a role in MAPKAPK2-mediated phosphorylation, which may represent a novel pathway mediating p38 MAPK-dependent inflammation PMID:12861023
23. dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface PMID:12865427
24. 14-3-3 was identified as a binding partner of MITF in osteoclast precursors, and overexpression of 14-3-3 in a transgenic model resulted in increased cytosolic localization of MITF and decreased expression of MITF target genes [14-3-3 zeta] PMID:16822840
25. 14-3-3:Shc scaffolds can act as multivalent signaling nodes for the integration of both phosphoserine/threonine and phosphotyrosine pathways to regulate specific cellular responses. PMID:19218246
26. Caspase-2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation. PMID:19531356

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UNIGENE: Mm.3360

KEGG: mmu:22631

STRING: 10090.ENSMUSP00000022894