vpr Antibody

Code: CSB-PA300245XA01HKQ

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0.1ml

0.1ml1ml

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Species Reactivity: Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P69727

Target Names

vpr

Alternative Names

vpr antibody; Protein Vpr antibody; R ORF protein antibody; Viral protein R antibody

Raised in

Rabbit

Species Reactivity

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

Immunogen

Recombinant Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1) vpr protein

Immunogen Species

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

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Target Background

Function(From Uniprot)

During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.; During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus. This function is crucial for viral infection of non-dividing macrophages. May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.

Subcellular Location

Virion. Host nucleus. Host extracellular space.

Protein Families

HIV-1 VPR protein family

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