TOP2 Antibody

Code: CSB-PA361947XA01SVG

Rate （N/A）
Review （0）

Size:

0.1ml

0.1ml1ml

US$Enquire

Quantity:

Species Reactivity: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

Send an Inquiry

Start an on-line Chat

Online ordering is currently available for U.S. customers only. For orders outside the U.S., please kindly submit an inquiry or start a chat with us.

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot NO.

P06786

Target Names

TOP2

Alternative Names

TOP2 antibody; TOR3 antibody; YNL088W antibody; N2244 antibody; DNA topoisomerase 2 antibody; EC 5.6.2.2 antibody; DNA topoisomerase II antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TOP2 protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

Antibody FAQs

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.

Gene References into Functions

Condensin DNA supercoiling activity correlates with Top2 intertwine removal during DNA replication. PMID:27716481
Topoisomerase II plays a central role in a molecular pathway for crossover interference PMID:25043020
Chromatin regulates DNA torsional energy via topoisomerase II-mediated relaxation of positive supercoils. PMID:24859967
the cell cycle delay depends on the divergent and catalytically inert C-terminal region of Topo II, indicating that transmission of a checkpoint signal may occur via the C-terminus PMID:24098144
Structure of topoisomerase II-DNA-nucleotide complex produces an unexpected interaction between DNA and a conformational transducing element in the ATPase domain, which is critical for both DNA-stimulated ATP hydrolysis and global topoisomerase activity. PMID:23022727
a topological change on DNA drives topoisomerase II to decatenate molecules during mitosis, potentially driving the full decatenation of the genome PMID:21393545
In eukaryotes, replication fork barriers, Rrm3, and Top2 coordinate replication fork progression and fusion at chromosomal termination regions, thus counteracting abnormal genomic transitions. PMID:20797631
structure of the DNA-binding and cleavage core of Saccharomyces cerevisiae topoisomerase II covalently linked to DNA through its active-site tyrosine at 2.5A resolution PMID:20485342
compromised Topo II function activates a yeast checkpoint system that operates by a novel mechanism PMID:16651657
structure of a complex between the DNA-binding and cleavage core of Saccharomyces cerevisiae Topo II (also known as Top2) and a gate-DNA segment PMID:18097402
kinetic and structural analysis of coupling between ATP binding and DNA cleavage by DNA topoisomerase II PMID:18403371
Top2 seems to play a novel role in centromeric chromatin compaction that is distinct from decatenation PMID:18701701
analysis of Top2 covalent complexes containing DNA single strand breaks PMID:18723844