Sod2 Antibody

Code: CSB-PA679571XA01DLU

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q00637

Target Names

Sod2

Alternative Names

Sod2 antibody; CG8905 antibody; Superoxide dismutase [Mn] antibody; mitochondrial antibody; EC 1.15.1.1 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Sod2 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

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Target Background

Function(From Uniprot)

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Gene References into Functions

Depletion of superoxide dismutases promotes muscular and neuronal ROS accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults. PMID:25801590
Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance. PMID:25091824
The functional SOD1 and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions. PMID:26030970
ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS is not essential for oocyte viability PMID:21212740
knockdown in the musculature has whole-organism consequences PMID:19545620
Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle. PMID:19546321
Overexpression of Cu,ZnSOD and MnSOD in transgenic Drosophila. PMID:11912910
Ablation of mitochondrial SOD2 through expression of a GAL4-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults. PMID:12456885
Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity. PMID:12743125
The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr, down-regulated MnSOD expression. PMID:12934716
SOD1 and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress PMID:12972424
Disruption of the protective effects of SOD2 on mitochondria manifests as profound changes in behavioral and demographic aging as well as exacerbated age-related pathology in the nervous system. PMID:18078670
switching moribund SOD2-deficient adults from normoxia into hypoxia arrests premature mortality and endows the survivors with a near-normal life PMID:18983909
Data show that the decline of several functional measures of aging occurs, in an accelerated fashion, in Sod2 mutants. PMID:19148770