Pde4a Antibody

Code: CSB-PA261418XA01RA

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Rattus norvegicus (Rat)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P54748

Target Names

Pde4a

Alternative Names

Pde4a antibody; cAMP-specific 3',5'-cyclic phosphodiesterase 4A antibody; EC 3.1.4.53 antibody; DPDE2 antibody

Raised in

Rabbit

Species Reactivity

Rattus norvegicus (Rat)

Immunogen

Recombinant Rattus norvegicus (Rat) Pde4a protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Gene References into Functions

ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion. PMID:23986500
PDE4A upregulation during cholestatic liver injury plays a role in inflammation and fibrosis. PMID:23887098
beta-adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PMID:23094097
These results indicate that PDE4A and PLAT may be susceptibility genes for schizophrenia in the Japanese population. PMID:21898905
Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes. PMID:18721873
cGMP and cAMP phosphodiesterase PDE4 and AMPK/NOX2 have a role in early cardiac hypertrophy induced by angiotensin II PMID:21151982
results suggest that XAP2 functionally interacts with PDE4A5 in cells. PMID:12810716
The results indicate that phosphodiesterase-4 blockers are strong stimulants of the respiratory network. We hypothesize that these or related agents may be potent tools for a treatment of drug-induced disturbances of breathing in (preterm) infants. PMID:16581183
In addition to the brain, (R)-[11C]rolipram binds selectively to PDE4 across all cardiac regions, skeletal muscle, lungs and pancreas, but not in the adipose tissues. PMID:17210463
The effects of increased cyclic AMP and glucocorticoid dexamethasone administration on Brucella melitensis-induced lipid peroxidation, Brucella suppressed antioxidant enzyme activities and PDE4 transcripts in rats are reported. PMID:17397885
unique tissue distribution of PDE4A8, combined with the evolutionary divergence of its N-terminus, suggest that this isoform may have a specific function in regulating cAMP levels in human skeletal muscle and brain PMID:18095939