NRG1 Antibody

Code: CSB-PA966535XA01CZD

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0.1ml

0.1ml1ml

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Species Reactivity: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q5A0E5

Target Names

NRG1

Alternative Names

NRG1 antibody; CAALFM_C704230WA antibody; CaO19.7150 antibody; Transcriptional regulator NRG1 antibody

Raised in

Rabbit

Species Reactivity

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Immunogen

Recombinant Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) NRG1 protein

Immunogen Species

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament-specific gene expression in response to inducing conditions. Plays a key role in biofilm formation and dispersion. Plays also the role of a negative regulator of virulence in mice models. Required for the expression of the cell wall genes RBR1.

Gene References into Functions

Candida albicans can express iron assimilation genes independently of NRG1 levels. PMID:22888912
Nrg1p as a key regulator of the C. albicans biofilm life cycle. PMID:20709787
The increased rate of hypha formation in C. albicans relative to C. dubliniensis in response to phagocytosis by macrophages and serum was associated with rapid downregulation of NRG1 expression in C. albicans. PMID:17927699

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Subcellular Location

Nucleus.

Database Links

KEGG: cal:CAALFM_C704230WA

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