MTM1 Antibody

Code: CSB-PA911338XA01DOA

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Arabidopsis thaliana

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

F4J3T8

Target Names

MTM1

Alternative Names

MTM1 antibody; At3g10550 antibody; F13M14.17 antibody; F18K10.13 antibody; Phosphatidylinositol-3-phosphatase myotubularin-1 antibody; AtMTM1 antibody; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase antibody; EC 3.1.3.95 antibody; Phosphatidylinositol-3-phosphate phosphatase antibody; EC 3.1.3.64 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana MTM1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Phosphatase with phosphoinositide 3'-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus. Required for recovery after water deprivation, via the accumulation of PtdIns5P upon dehydration; high PtdIns5P levels mediate ATX1 cytoplasmic localization, thus down-regulating the expression of ATX1-dependent genes. Confers sensitivity to soil-water-deficit stress.

Gene References into Functions

AtMTM1 is involved in elevating the cellular level of phosphatidylinositol 5-phosphate in response to dehydration stress. PMID:22324391
AtMTM1 encodes a phosphoinositide 3′-phosphatase related to the animal myotubularins. AtMTM1 and the Arabidopsis chromatin modifier ATX1, co-regulate overlapping set of genes under drought conditions. [AtMTM1] PMID:19901554
study reports that At3g10550, encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins (AtMTM1); identifed an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions PMID:19901554

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Subcellular Location

Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Present in granular particles of varying abundance and size at the cell periphery and throughout the cytoplasm.

Protein Families

Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily

Tissue Specificity

Mostly expressed in siliques and leaves (including hydathodes), and, to a lower extent, in flowers and roots.

Database Links

UNIGENE: At.46683

KEGG: ath:AT3G10550

STRING: 3702.AT3G10550.1

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