Msx1 Antibody

1. Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development. PMID:27917906
2. Full digit tip was regenerated only in the MSX1/2 group and was related to boosted Bmp4, Fgf8, and K14 gene expression and to limb-patterning properties resulting from Msx1 and Msx2 overexpression. PMID:28461333
3. endocytic adaptor protein Numb regulates the balance between neural and non-neural fates in Msx1 progenitors. PMID:28011038
4. these data reveal a novel mechanism that the Bmp4-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists. PMID:27713059
5. Msx1 and Msx2 are expressed both in Primordial germ cell precursors and in neighboring somatic cells. Msx1(-/-); Msx2(-/-) mutant embryos have defects in Primordial germ cell migration as well as a reduced number of Primordial germ cells. PMID:27435625
6. Functional analysis of each TE revealed step-by-step retroposition/transposition and co-option together with acquisition of a binding site for Msx1 for its full enhancer function during mammalian evolution. PMID:27741242
7. Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (Msx) genes Msx1d/d/Msx2d/d uteri. PMID:26667042
8. MSX1 linked the arterial shear stimulus to arteriogenic remodeling by activating the endothelial but not medial layer to a proinflammatory state because EC but not smooth muscle cell PMID:26391659
9. findings highlight an unexpected role of uterine Msx in limiting aberrant inflammatory responses to maintain embryonic diapause PMID:25931120
10. Msx1 and Msx2 are direct transcriptional targets of Lhx2. PMID:25460335
11. Msx1 appears to act as a modeling factor for membranous bone. PMID:24929242
12. analysis of a BMP signaling pathway that regulates the expression of the odontogenic gene Msx1 and determines the fate of dental mesenchyme during early tooth development PMID:25274628
13. Msx1 supports vascular mineralization by directing the osteogenic programming of aortic progenitors in diabetic arteriosclerosis. PMID:25056439
14. Msx1 and Msx2 proteins activate Atoh1 transcription by specifically interacting with several homeodomain binding sites in the Atoh1 3' enhancer. PMID:24715462
15. Study concludes that MSX1 may promote proliferation and prevent the differentiation of dental mesenchymal cells by the inhibition of Bmp2 and Bmp4 expression. PMID:24028588
16. Msx1 functions as a negative regulator early in pituitary development by repressing the gonadotrope-specific alphaGSU and GnRHR genes. PMID:23371388
17. Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development. PMID:23720046
18. Differential homeobox expression contributes to phenotypic differences between healthy and atherosclerotic blood vessels. PMID:23448971
19. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. PMID:23506836
20. Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation PMID:23250216
21. Msx1 and Msx2 are critical for epithelial-mesenchymal interactions during development, and also play crucial roles in embryo implantation. Loss of Msx1/Msx2 expression correlates with altered uterine luminal epithelial cell polarity. PMID:22100262
22. PIAS1 negatively regulates ubiquitination of Msx1 homeoprotein independent of its SUMO ligase activity. PMID:21717107
23. Upon meiosis initiation, Msx1 and Msx2 genes were strongly expressed in the fetal ovary. In Msx1/Msx2 double mutant embryos, there was a decrease in the number of meiotic cells. PMID:22071108
24. Disturbance of the balance between Msx1 sense and antisense RNA status may be associated with tooth agenesis and bone loss. PMID:21625063
25. Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. PMID:21777520
26. Study demonstrate that mesenchymal expression of Msx1 and Msx2 is required for proper Shh and Bmp4 signaling to specify digit number and identity. PMID:21465616
27. Both Msx1 and Msx2 are required for the recruitment of a population of neural crest-derived vascular smooth muscle cells. PMID:21693521
28. Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 and Msx1 mRNA expression in the developing tooth mesenchyme. PMID:21420399
29. The Tgf-beta(3) null mutant mouse palate presents several cellular anomalies that lead to the appearance of cleft palate reveals misexpression of EGF and Msx-1. PMID:20881363
30. MSX1 and TGF-beta3 are direct targets of FOXE1. PMID:21177256
31. Msx1/Dlx5 interaction is crucial for osteogenic induction during frontal bone development. PMID:20824629
32. Msx1 is expressed in the cardiac cushions but not in the myocardium. In Msx2-null mice, Msx1 is not ectopically expressed in the myocardium. PMID:20225205
33. Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head. PMID:20398647
34. Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. PMID:20123092
35. Msx1 controls a genetic hierarchy involving BMP and Shh signals that regulates the growth of the anterior region of palate during mammalian palatogenesis PMID:12163415
36. Msx1 homeogene antisense mRNA in mouse dental and bone cells. PMID:12489151
37. Results demonstrated unimpaired auditory function in Msx1 or 2 (-/-) mice, and suggest that the malleal processus brevis is not necessary for sound transmission and seems dispensable for normal hearing and balance in mammals. PMID:12701100
38. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. PMID:12941628
39. These data identify a signaling pathway essential for digit regeneration, in which Msx1 functions to regulate BMP4 production. PMID:12944425
40. Ectopic expression of Bmp4 in Msx1 mutants restores the expression of Dlx5, but not Cbfa1, in the dental mesenchyme, and rescues the expression of both Dlx5 and Cbfa1 in the developing alveolar bone PMID:14654219
41. Msx1 and Msx3 can mediate distinct aspects of Bmp signaling during neural tube development PMID:14973289
42. Msx1 disruption leads to diencephalon defects and hydrocephalus. PMID:15188430
43. Msx1 and histone H1b bind to a key regulatory element of MyoD, a central regulator of skeletal muscle differentiation, where they induce repressed chromatin; Msx1 and H1b cooperate to inhibit muscle differentiation in cell culture PMID:15192231
44. Study of Msx1 null mutant mice concludes that Msx1 is necessary for the synthesis of subcommissural organ glycoproteins, which would then be required for maintenance of an open cerebral aqueduct. PMID:15217086
45. Msx1 may be associated with homeostasis and blood-brain barrier function in the adult mouse brain. PMID:15312901
46. MSX and DLX have roles in contributing to spatiotemporal regulation of GnRH transcription during development PMID:15743757
47. These findings indicate that Msx1 and Msx2 play roles in concert during embryonic ventral abdominal wall formation. PMID:15803476
48. plays a role in crucial processes during limb morphogenesis along all three axes PMID:15930102
49. Data show that GRG proteins, including GRG5, interact with two regulators of GnRH transcription, the homeodomain proteins MSX1 and OCT1, and regulate GnRH promoter activity. PMID:16002402
50. BMP2/BMP4 signalling through SMAD 8 is required for transcriptional activation of the mouse Msx1 gene. PMID:16101586

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UNIGENE: Mm.256509

KEGG: mmu:17701

STRING: 10090.ENSMUSP00000058354