Camk2b Antibody

Code: CSB-PA004466XA01MO

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0.1ml

0.1ml1ml

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Species Reactivity: Mus musculus (Mouse)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P28652

Target Names

Camk2b

Alternative Names

Camk2b antibody; Camk2d antibody; Calcium/calmodulin-dependent protein kinase type II subunit beta antibody; CaM kinase II subunit beta antibody; CaMK-II subunit beta antibody; EC 2.7.11.17 antibody

Raised in

Rabbit

Species Reactivity

Mus musculus (Mouse)

Immunogen

Recombinant Mus musculus (Mouse) Camk2b protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Gene References into Functions

Region-specific overexpression of betaCaMKII in dentate gyrus (DG) impairs behavioral flexibility, and severely attenuates the NMDAR-dependent long-term depression (LTD) in DG medial perforant path, which is further confirmed by the diminished AMPAR internalization and dephosphorylation during LTD. PMID:27993520
data suggest that phosphorylation of CaMKIIbeta through the mGluR/IP3R1/PKC signaling pathway represses excessive spine formation and elongation in mature Purkinje cells. PMID:28607044
The molecular, temporal and region-specific requirements of the CAMK2B in mouse locomotion have been described. PMID:27244486
Study used an unbiased semiquantitative proteomics approach to identify biologically relevant phosphorylation sites on both CaMKIIa and CaMKIIb PMID:25650780
CaMKK/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia. PMID:23868268
Our data point toward a critical role of CaMKIIbeta in regulating oligodendrocyte maturation and CNS myelination via an actin-cytoskeleton-regulatory mechanism PMID:23785157
Muscle-specific CamkIIss isoform is critical for receptor recycling and may provide a mechanism by which the postsynaptic acetylcholine receptor density is maintained at the neuromuscular junction in vivo. PMID:20844140
is expressed in motor neurons during axon outgrowth and is part of slow axonal transport. PMID:11891785
accumulated in the nuclei of brain cells by pentylenetetrazol-mediated seizure via cellular mechanisms other than transcriptional and post-transcriptional regulation PMID:11897160
Ca/CaMK II activation plays an important role in the transmission of GnRH signals from the plasma membrane to the LH subunit genes. PMID:12746302
Expression of an active form of CaMKII beta after 1 day of T cell activation enhances initial proliferation and cytotoxic T cell activity, but induces profound unresponsiveness to peptide restimulation. PMID:15843557
activated CaMKII directly phosphorylated the recombinant COOH-terminal region of FAK at a residue equivalent to Ser-843 PMID:15845548
CaM kinase IIdelta2 was involved in the GnRH-induced activation of MAP kinase in GT1-7 cells. PMID:17706588
betaCaMKII activity in the dentate gyrus selectively impaired long-term potentiation in the dentate perforant path, but not in the CA1 Schaffer collateral pathway. PMID:17913888
We found that betaCaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse PMID:19503086
Deletion studies indicated three important parts of beta CaM kinase II: beta-specific insertion 2, the association domain, and the oligomeric form; all 3 play an important role in its cellular distribution. PMID:11532017

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Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse.

Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily

Database Links

UNIGENE: Mm.439733

KEGG: mmu:12323

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