Camk2a Antibody

1. Fluorescence resonance energy transfer studies confirm that the extended state of CaMKII-alpha resolved by electron microscopy is the predominant form of the holoenzyme, even under molecular crowding conditions. PMID:28589927
2. Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model. PMID:28230177
3. Its pathway may promote reactive oxygen species generation in the early state Alzheimer's disease and eventually contribute to the exacerbation of pathological phenotype. PMID:29602494
4. Study showed the significance of TLR4 in upregulation of MAPK/ErK in NMDAR hypofunction schizophrenic-mouse model. This is characterized by a decrease in hippocampal IGF-1R/CaMKIIalpha, and social interaction behavioral deficits. Ultimately, hippocampal TLR4 knockdown rescued IGF-1R/CaMKIIalpha decline and prevented behavioral deficits by reducing MAPK/ErK expression. PMID:29137928
5. Hyperlipidemia induced by a high-fat diet was associated with increased expression and activity of CaMKII in heart. PMID:28662005
6. Data show that calcium/calmodulin protein kinase II (CaMKII)-mediated modulation of neuronal sodium current impacts neuronal excitability in SCN2A sodium channel alpha subunit Scn2a(Q54) mice and may represent a therapeutic target for the treatment of epilepsy. PMID:28137877
7. Results show that aging impairs the training-induced upregulation of autophosphorylated (T286) alphaCaMKII in the CA3 stratum radiatum of the hippocampus. This indicates that distinct age-related mechanisms underlie CFC that may rely more heavily on NMDA receptor-dependent plasticity in young age. PMID:28648815
8. This study found that the Camk2a gene showed a downregulated profile only in the Inflexible when compared to the Light ethanol drinkers group. PMID:28714806
9. Results suggest that the increased expression of calcium/calmodulin dependent protein kinase II in the lateral habenula is instrumental for morphine-driven aversive behaviors. PMID:28527717
10. our findings demonstrated that TINCR could attenuate myocardial hypertrophy by epigenetically silencing of CaMKII, which may provide a novel therapeutic strategy for cardiac hypertrophy. PMID:28548932
11. CaMKII is a target of PTENalpha phosphatase and that PTENalpha is an essential element in the molecular regulation of neural activity. PMID:28636948
12. In FHC-linked TnT-mutated hearts, RyR2 is susceptible to CaMKII-mediated phosphorylation, presumably because of a mutation-linked increase in diastolic [Ca(2+)]i, causing aberrant Ca(2+) release leading to lethal arrhythmia. PMID:29402414
13. Data suggest that alphaCaMKII autophosphorylation-dependent remodeling of glutamatergic synapses is a plausible mechanism for the regulation of the alcohol addiction-related behaviors. PMID:26572936
14. astrocytic IL-17A plays important roles in the maintenance of neuropathic pain through CaMKII/CREB signaling pathway in spinal cord. PMID:26166359
15. Wip1 phosphatase plays a vital role in regulating hippocampal synaptic plasticity by modulating the phosphorylation of CaMKII. PMID:27158969
16. Destabilization of PGC1a is attributable to decreased p38 MAPK activation via diminished CaMKII signaling. Thus, we elucidate a pathway downstream of Ca(2+)-mediated CaMKII activation that is dysfunctional in C3KO(Capn3 knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation PMID:27005420
17. In young mice, 30% of adult CaMKIIalpha expression is sufficient for normal long-term potentiation in the hippocampus and cerebral cortex. PMID:27535377
18. Findings demonstrate that Thr286 phosphorylation of CaMKII plays an important role in induction of long-term potentiation (LTP) by integrating Ca(2+) signals, and it greatly promotes, but is dispensable for, the activation of CaMKII and LTP. PMID:28521133
19. The present study demonstrates, for the first time, that ROS-dependent activation of CaMKII mediates altered Ca2+ handling and contractile dysfunction observed in the setting of sepsis. PMID:27648519
20. these data implicate the importance of subunit stoichiometry as another regulatory mechanism of PKA activity and lipid metabolism. PMID:27496951
21. Thus, taken into consideration the mechanism that controls the upregulation of maturation genes involved in synaptic formation, these results indicate that Etv1 orchestrates the activity-dependent regulation of both maturation and immaturation genes in developing granule cells and plays a key role in specifying the identity of mature granule cells in the cerebellum. PMID:27059140
22. Pharmacological and genetic studies using CaMKII antagonists and genetically modified [alpha]-CaMKII mice have shown that blockade or reduction of CaMKII reduces nicotine reward PMID:26292186
23. The study shows advanced glycation end products (AGEs) resulted from ribosylation activate calcium-/calmodulin-dependent protein kinase type II (CaMKII), a key kinase responsible for Tau hyperphosphorylation. PMID:26095350
24. HDAC2 may regulate the expression of immediate early genes, in part, by prolonging the actions of pCREB in the mouse nucleus accumbens. PMID:26300473
25. The results suggest that CaMKII-dependent TnI phosphorylation is involved in FDMCD and the consequent FDAR and that CaMKII inhibition removes this mechanism and thus induces diastolic dysfunction. PMID:26297240
26. Results indicate that alpha-Ca(2+)/calmodulin-dependent protein kinase II overexpression in the forebrain impairs behavioral flexibility and NMDAR-dependent long-term depression in the medial prefrontal cortex. PMID:26415772
27. As up-regulation of epithelial barriers is essential for the prevention of chronic inflammatory diseases, the identification of CaMKII as a modulator of TJ function paves the way for the development of new drugs to treat these diseases. PMID:26281891
28. Binge-like drinking decreased Camk2a phosphorylation in amygdala from adolescent mice, with no effect in adult mice. PMID:26247621
29. This study show that CaMKII regulates the flow of sensory information in Abeta-LTMR sensory neurons at multiple levels, including impulse generation, Action potential propagation, and dorsal horn synaptic transmission PMID:26490852
30. CaMKIIalpha selectively regulates mGluR1a and mGluR5a ERK1/2 signaling. PMID:25885040
31. Results identify CaMKII isoform phosphorylation sites and a network of synaptic protein interactions that are sensitive to the abrogation of Thr286 autophosphorylation of CaMKIIa PMID:25650780
32. Results suggest that inhibitory autophosphorylation of CAMKIIa regulates the threshold for induction of both long-term potentiation and long-term depression PMID:24480420
33. showed polypyrimidine tract binding protein (PTBP)-dependent alternative splicing of CaMKIIalpha transcripts in the lens PMID:25540577
34. Ca2+/calmodulin-dependent protein kinase-II (CaMKII) has a key role in the plasticity of glutamatergic synapses of the brain. PMID:25290264
35. VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation. PMID:25644714
36. Genetic deletion of Camk2a impaired the locomotor response of mice to ecstasy. PMID:26019340
37. IRBIT suppresses CaMKIIalpha activity and contributes to catecholamine homeostasis through TH phosphorylation. PMID:25922519
38. Our results demonstrate unanticipated, fundamentally important roles for UNC-43/CaMKII in the regulation of synaptic strength. PMID:25843407
39. results provide new mechanistic insight into the role of alphakap in regulating the stability of the postsynaptic apparatus of neuromuscular synapses. PMID:25834039
40. data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII activation. PMID:25834051
41. Angiotensin II activates PKA and CaMKII via NOX2, which results in disturbed sodium and calcium currents (via PKA) and enhanced diastolic sarcoplasmic reticulum Calcium leakage. PMID:25073061
42. Data show that resolvin D1 decrease nuclear 5-lipoxygenase (5-LOX) and the leukotrienes LTB4:LXA4 ratio by macrophages lacking calcium-sensitive kinase calcium-calmodulin-dependent protein kinase II (CaMKII). PMID:25246560
43. Therefore, these studies reveal a novel interaction between CAPN3 and CaM and identify CaM as the first positive regulator of CAPN3 activity PMID:25389288
44. Calmodulin and PI(3,4,5)P cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production. PMID:25097034
45. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. PMID:24949568
46. Aging increases both the oxidation and CaMKII-phosphorylation of RyR2, which results in calcium leak and atrial fibrillation initiation. PMID:24576293
47. This study demonistrated that the requirement for alphaCaMKII in the forebrain, but not the cerebellum, in spatial and contextual learning. PMID:25143599
48. Data indicate that nitric oxide directly affects Ca-calmodulin-dependent protein kinase (CaMKII) to sustain its activity leading to the increase in sarcoplasmic reticulum calcium leak. PMID:24498331
49. Loss of alpha-CaMKII from adult-generated granule cells is associated with impaired hippocampus-dependent learning. PMID:25186740
50. Our study presents novel evidence that CaMKII expression in vivo is regulated by a negative feedback loop following oxidative activation. PMID:24418021

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UNIGENE: Mm.131530

KEGG: mmu:12322

STRING: 10090.ENSMUSP00000099952