Il7r Antibody

1. Memory formation and long-term maintenance of memory type I innate lymphoid cells via a lymph node-liver axis is mediated via IL-7Ralpha expression. PMID:30451860
2. IL-7 receptor (IL-7R) is not strictly required for the development of any innate lymphoid cells subset. PMID:28361874
3. the results indicate that endogenous IL-7R signals promote Th1 and Tc1 responses and IFN-gamma- and TNF-alpha production to sustain the persistence of SS-like sialadenitis in NOD mice. These findings suggest that IL-7 and Th1 cytokines could serve as promising therapeutic targets for this prevalent autoimmune disease. PMID:29680668
4. this study demonstrates a key role for IL-7R in the generation of microenvironments required for thymic dendritic cells PMID:28890536
5. show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Ralpha and the induction of transcription factor Sall3 PMID:28794449
6. results demonstrated that forced expression of IL-7R not only improved the functionality of tolerized CD8 T cells, it also acted in synergy with PDL-1 deficiency to further promote CD8 T cell cytotoxicity to self antigens PMID:29272267
7. this study shows that short-term blockade of IL-7Ralpha induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice PMID:28356069
8. results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin responsiveness and that IL-4 can upregulate IL-7Ralpha on DCs. PMID:28404633
9. IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver PMID:26235516
10. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP can replace IL-7 in providing these signals. PMID:27325567
11. Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a axis. PMID:26876184
12. results suggest that LNK suppresses IL-7R/JAK/STAT signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations. PMID:26974155
13. The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin resistance in mice. PMID:26152662
14. IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice. PMID:26450881
15. This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs. PMID:26336149
16. Inhibition of the IL-7 receptor inhibits tumor growth in murine models of melanoma. PMID:24619454
17. The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression PMID:25037454
18. data suggest that IL-7Ralpha Tyr(449) was essential for IL-7Ralpha signaling in bone marrow B cell development and survival. PMID:25143441
19. The development and survival but not function of follicular B cells is dependent on IL-7Ralpha Tyr449 signaling. PMID:24551160
20. interleukin-7 receptor mutants induce early T cell precursor acute lymphoblastic leukemia by the block of thymocyte differentiation at the double negative 2 stage at which myeloid lineage and T lymphocyte developmental potential coexist. PMID:24687960
21. The transcription factor GATA3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells. PMID:24631153
22. Expression of insertion mutation in combination with a Notch1 mutant led to the development of much more aggressive T-acute lymphoblastic leukemia than with wild-type IL7Ralpha. PMID:24174626
23. These data indicate that IL7R+ B cells have a proinflammatory role in arthritis which can be inhibited by the sympathetic neurotransmitter norepinephrine via inhibition of IL-7R signalling. PMID:23505234
24. IL-7Ralpha transgenesis or T-cell-specific ablation of Gfi-1 restored IL-7Ralpha expression and largely ameliorated the development and homeostasis defects of TGF-beta-receptor-deficient T cells. PMID:23932572
25. We have analyzed the discrete contributions of the antibody constant (Fc) and IL-7-binding (Fab) domains to the mechanism of binding to IL-7R. PMID:23610371
26. IL7Ralpha has a role in potentiating IL-7 bioactivity and in promoting autoimmunity PMID:23610432
27. Pre-B cell receptor (BCR) cooperates with IL-7R in expanding the pre-B cell pool, but it also critically controls the differentiation program that shuts off the c-Myc gene in large pre-B cells. PMID:23420891
28. IL-7Ralpha differentially controls development and maturation of thymocyte subpopulations in late developmental stages. PMID:23267098
29. the in vivo regulatory role of Gfi1 was specific for CD8(+), and not CD4(+) T cells or immature thymocytes. These results identify Gfi1 as a specific transcriptional repressor of the Il7r gene in CD8 T lymphocytes in vivo. PMID:22865857
30. show that interleukin-17A (IL-17A)-producing IL-7Ralpha(+) innate lymphoid cells (ILCs) were potent promoters of disease in Tbx21(-/-)Rag2(-/-) ulcerative colitis (TRUC) mice PMID:23063332
31. The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D. PMID:22733769
32. Blockade of IL-7/IL-7Ralpha signaling in IL-7-dependent p53(null) cells reduced POT1 expression and caused telomere and chromosome abnormalities similar to those observed in DKO lymphomas. PMID:22281704
33. Data suggest that this decrease in IL-7Ralpha is associated with defective hematopoietic development in Down Syndrome. PMID:21504363
34. Increased IL-7Ralpha (CD127) expression correlated, as previously reported with increased turnover of CD4 memory cells, however, this was not linked to protection or enhanced response to rechallenge PMID:22039531
35. a novel function of Efnb1 and Efnb2 in stabilizing IL-7Ralpha expression at the post-translational level PMID:22069310
36. IL-7R-mediated signaling not only maintains the size but also impacts the diversity of the naive T-cell repertoire. PMID:21339767
37. IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. PMID:21258009
38. High expression of IL-7 receptor (IL-R)alpha on colitic CD4-positive memory T cells, but not on other cells, is essential for the development and persistence of chronic colitis. PMID:21217010
39. These findings highlight that IL-7Ralpha confers susceptibility by influencing autoimmune Th1/Th17 responses in experimental autoimmune encephalomyelitis model of multiple sclerosis . PMID:20861865
40. T-cell homeostasis is maintained through a concerted regulation of Gfi-1-IL-7R-controlled cytokine responsiveness and ERK-mediated TCR signaling strength by the Cdc42-PAK1 signaling axis. PMID:20937872
41. increased expression on activated FOXP3+CD4+ regulatory T cells PMID:20690182
42. HIV Tat protein colocalizes with CD127 at the cell surface of resting CD8-positive T lymphocytes. PMID:20660706
43. Sin1-mTORC2 suppresses rag1,2 and il7r gene expression through Akt2 in B cells. PMID:20705244
44. study shows that IL-7Ralpha Y449 is important for lymphocyte transformation PMID:20440272
45. Pre-pro-B cell growth-stimulating factor (PPBSF) upregulates IL-7Ralpha chain expression and enables pro-B cells to respond to monomeric IL-7. PMID:12184921
46. IL-7R(alpha)(-/-) mice lack detectable numbers of all downstream early B lineage precursors, including pre-pro-B cells PMID:12208884
47. IL-7R signals are able to stimulate T cell proliferation in lymphopenic hosts independently of lck-mediated T cell receptor (TCR) signaling, but they can also synergize with TCR signals to facilitate proliferation. PMID:12244169
48. IL-2 signaling can diminish IL-7Ralpha expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism. PMID:12354940
49. The inability of B-cell progenitors in the thymus to mature is due to down-regulation of IL7Ralpha through a type 1 IFN receptor-independent mechanism PMID:12393710
50. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency PMID:12433363

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UNIGENE: Mm.389

KEGG: mmu:16197

STRING: 10090.ENSMUSP00000003981