HDAC1 Antibody

Code: CSB-PA213658XA01OFG

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Oryza sativa subsp. japonica (Rice)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q7Y0Y8

Target Names

HDAC1

Alternative Names

HDAC1 antibody; HDA702 antibody; Os06g0583400 antibody; LOC_Os06g38470 antibody; P0498C03.28-1 antibody; Histone deacetylase 1 antibody; OsHDAC1 antibody; EC 3.5.1.98 antibody

Raised in

Rabbit

Species Reactivity

Oryza sativa subsp. japonica (Rice)

Immunogen

Recombinant Oryza sativa subsp. japonica (Rice) HDAC1 protein

Immunogen Species

Oryza sativa subsp. japonica (Rice)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (Probable). Regulates negatively the expression of the NAC48/NAC6 gene that controls root growth in seedlings. Epigenetically represses the expression of NAC48/NAC6 by deacetylating 'Lys-9' (H3K9ac), 'Lys-14' (H3K14ac) and 'Lys-18' (H3K18ac) of histone H3, and 'Lys-5' (H4K5ac), 'Lys-12' (H4K12ac) and 'Lys-16' (H4K16ac) of histone H4. Functions in the regulation of gene expression in the whole genome. Acts as chromatin remodeling regulator to promote the formation of a repressive chromatin state. Functions with MODD via its interaction with TPR3, to down-regulates the histone acetylation level at BZIP46 target genes. BZIP46 is a positive regulator of abscisic acid (ABA) signaling and drought stress tolerance.

Gene References into Functions

OsHDAC1 epigenetically regulates the OsNAC6 gene, and that this is primarily responsible for the alteration of root development in rice seedlings. PMID:19453457

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Subcellular Location

Nucleus.

Protein Families

Histone deacetylase family, HD Type 1 subfamily

Tissue Specificity

Expressed in roots and leaves.

Database Links

UNIGENE: Os.10708

KEGG: osa:4341387

STRING: 39947.LOC_Os06g38470.1

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