gag Antibody

Code: CSB-PA321199XA01HQG

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0.1ml

0.1ml1ml

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Species Reactivity: Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P14076

Target Names

gag

Alternative Names

gag antibody; Gag polyprotein antibody; Pr53Gag) [Cleaved into: Matrix protein p19 antibody; MA); Capsid protein p24 antibody; CA); Nucleocapsid protein p15-gag antibody; NC-gag)] antibody

Raised in

Rabbit

Species Reactivity

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)

Immunogen

Recombinant Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) gag protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.; Matrix protein.; Forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.; Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.

Gene References into Functions

Altogether, these data suggest that Gag targeting and membrane binding mediated by HTLV-1 matrix domain does not require phosphatidylinositol-(4,5)-bisphosphate and that distinct mechanisms regulate HIV-1 and HTLV-1 Gag membrane binding. PMID:21289126
Nedd4.1 and Tsg101 act successively in the assembly process of HTLV-1 to ensure proper Gag trafficking through the endocytic pathway up to late endosomes where the late steps of retroviral release occur PMID:15126635
beta-hairpin contributes to overall structure of mature capsid protein; differences in the backbone dynamics of the beta-hairpin contribute to mature capsid structure, possibly introducing flexibility into interface formation during proteolytic maturation PMID:15569685
findings have shown that HTLV-1 Gag associates with CD82-enriched plasma membrane microdomains in Jurkat T cells PMID:16325219
HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively. PMID:16400878
data show that the HTLV-1 matrix protein may be phosphorylated by cellular ERK-2 kinase and indicate that phosphorylation of L-domain-containing proteins may be a common post-translational modification required for appropriate retroviruses budding PMID:16635502