fgf1 Antibody

Code: CSB-PA754234XA01DIL

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Danio rerio (Zebrafish) (Brachydanio rerio)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q6PBT8

Target Names

fgf1

Alternative Names

fgf1 antibody; fgf-1 antibody; zgc:73249Putative fibroblast growth factor 1 antibody; FGF-1 antibody; Acidic fibroblast growth factor antibody; aFGF antibody; Heparin-binding growth factor 1 antibody; HBGF-1 antibody

Raised in

Rabbit

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) fgf1 protein

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.

Gene References into Functions

Fgf1 was confirmed as the overnutrition-induced beta-cell differentiation signal, as inactivation of fgf1 abolished the compensatory beta-cell differentiation. PMID:26420862
Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina. PMID:26428010
This study demonistrated that Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish. PMID:22649227
Data suggest that elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitment into the heart field during evolution, increasing the size of the heart. PMID:21750034
fgf1 is required for normal differentiation of erythrocytes in zebrafish primitive hematopoiesis. PMID:17219402