Mmp2 Antibody

Code: CSB-PA238276XA01DLU

Rate （N/A）
Review （0）

Size:

0.1ml

0.1ml1ml

US$Enquire

Quantity:

Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

Send an Inquiry

Start an on-line Chat

Online ordering is currently available for U.S. customers only. For orders outside the U.S., please kindly submit an inquiry or start a chat with us.

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot NO.

Q8MPP3

Target Names

Mmp2

Alternative Names

Mmp2 antibody; CG1794Matrix metalloproteinase-2 antibody; Dm2-MMP antibody; EC 3.4.24.- antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Mmp2 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

Antibody FAQs

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Has metalloproteinase activity. Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue. Required for growth of the dorsal air sac primordium and development of the dorsal air sacs. Promotes embryonic motor axon fasciculation. Cleaves and activates frac to promote motor axon bundling during outgrowth. Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites grow. Involved in inhibition of follicle stem cell proliferation by cleaving Dlp, inhibiting its interaction with wg and preventing Dlp-mediated spreading of wg to follicle stem cells to enhance their proliferation. Plays a role in wound healing. Involved in fat body dissociation which occurs during metamorphosis by degrading basement membrane components, leading to destruction of cell-basement membrane junctions. Required for posterior follicle cell degradation and ovulation.

Gene References into Functions

there are only two MMP genes in Drosophila, DmMmp1 and DmMmp2, which makes Drosophila an attractive system to analyze the basis of MMP specificity. Previously, Drosophila MMPs have been categorized by their pericellular localization, as Mmp1 appeared to be secreted and Mmp2 appeared to be membrane-anchored, suggesting that protein localization was the critical distinction in this small MMP family PMID:28300207
inhibition of ECM degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration PMID:29563183
Data indicate that matrix metalloproteinases mmp1 and mmp2 mutants have distinct heart phenotypes. PMID:28192468
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2+ as the second messenger. PMID:26473732
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells. PMID:25695427
As a Wnt signaling antagonist, MMP2 cleaves the glypican, reducing the ability of Dlp to interact with the Wnt ligand and promote its distribution. PMID:25267296
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila PMID:21978772
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila. PMID:21471368
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes PMID:20412776
Mmp2 expression in the developing air sac is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling. PMID:20152186
complete base sequence given for a 758 residue polypeptide PMID:11967260
Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. PMID:12530966
MMP activity is essential for embryonic motor axon fasciculation PMID:18045838
findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix PMID:19751719

Hide All

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Peptidase M10A family

Tissue Specificity

Widely expressed during embryogenesis including in the mesoderm, developing gut, central and peripheral nervous systems and imaginal disks. In the embryonic nervous system, expressed in neurons and glia. In third instar larvae, strongly expressed in the m

Database Links

UNIGENE: Dm.11246

KEGG: dme:Dmel_CG1794

STRING: 7227.FBpp0087585

Promotions