CTSK Antibody

Code: CSB-PA006192ZA01RB

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Oryctolagus cuniculus

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P43236

Target Names

Ctsk

Alternative Names

Cathepsin K (EC 3.4.22.38) (Protein OC-2), CTSK

Raised in

Rabbit

Species Reactivity

Oryctolagus cuniculus

Immunogen

Recombinant Oryctolagus cuniculus CTSK protein

Conjugate

Non-conjugate

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (12-14 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

Gene References into Functions

The authors showed CTSK upregulation in human lung specimens and elevated serum CTSK levels of patients with tuberculosis, compared with controls. PMID:26416658
Down-regulation of cathepsin K in synovium at the initial stage of osteoarthritis significantly accelerated cartilage degeneration. PMID:19644873

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Subcellular Location

Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side.

Protein Families

Peptidase C1 family

Tissue Specificity

Predominantly expressed in osteclasts (bones).

Database Links

UNIGENE: Ocu.6195

KEGG: ocu:100009334

STRING: 9986.ENSOCUP00000009540

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