cftr Antibody

Code: CSB-PA282472XA01DIL

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Danio rerio (Zebrafish) (Brachydanio rerio)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q1LX78

Target Names

cftr

Alternative Names

cftrCystic fibrosis transmembrane conductance regulator antibody; EC 5.6.1.6 antibody; ATP-binding cassette sub-family C member 7 antibody; Channel conductance-controlling ATPase antibody; cAMP-dependent chloride channel antibody

Raised in

Rabbit

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) cftr protein

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Required for normal fluid homeostasis in the gut. Required for normal volume expansion of Kupffer's vesicle during embryonic development and for normal establishment of left-right body patterning. Required for normal resistance to infection by P.aeruginosa strain PA14 and strain SMC573.

Gene References into Functions

study revealed an important role of cystic fibrosis transmembrane conductance regulator (CFTR) acting as an ion channel in regulating primordial germ cell migration during early embryogenesis PMID:29930176
Molecular dynamics of the cryo-EM CFTR structure PMID:28774558
Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening. PMID:28735752
Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis-causing missense mutational sites are identical. PMID:27912062
Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis of the human pancreas. PMID:25592226

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Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

ABC transporter superfamily, ABCC family, CFTR transporter (TC 3.A.1.202) subfamily

Tissue Specificity

Detected in gut epithelium (at protein level). Detected in kidney, spleen, intestine and liver. Detected in pancreatic duct epithelium at 5 dpf and throughout adult life.

Database Links

UNIGENE: Dr.74099

KEGG: dre:559080

STRING: 7955.ENSDARP00000060242

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