cdc42 Antibody

Code: CSB-PA934486XA01SXV

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0.1ml

0.1ml1ml

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Species Reactivity: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Product Details
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Target Background

Product Details

Uniprot NO.

Q01112

Target Names

cdc42

Alternative Names

cdc42 antibody; SPAC110.03Cell division control protein 42 homolog antibody; CDC42Sp antibody

Raised in

Rabbit

Species Reactivity

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Immunogen

Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) cdc42 protein

Immunogen Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Involved in development of cell polarity during the cell division cycle.

Gene References into Functions

Cdc42 activation pattern by GEF1 and Scd1 promotes different events during cytokinesis. PMID:26941334
cells evolved highly robust symmetry-breaking mechanisms that rely on feedback amplification of local Cdc42 activity. In turn, local Cdc42 activity favors Cdc42 accumulation because active Cdc42 is poorly mobile relative to the inactive form. PMID:26338468
Regulation of Cdc42 activity and localization and polarized cell growth in Schizosaccharomyces pombe. [Review] PMID:24450652
REVIEW: Cdc42 dynamics in the control of fission yeast cell polarization PMID:24256285
findings show that feedbacks regulating Cdc42 oscillations and spatial self-organization appear to provide a flexible mechanism for fission yeast cells to explore polarization states and to control their morphology PMID:22604726
The GTPase Rho3 also suppressed cdc42L160S thermosensitivity, restored exocyst localization and AP secretion. PMID:21899677
The Rga4 and the Scd1 establish a gradient of activated Cdc42 within the cellular tip plasma membrane, and it is this gradient that determines cell growth-zone size and normal cell width. PMID:21849474
Studies indicate that Once Cdc42 is polarized to the presumptive bud site, it organizes the actin cytoskeleton, and the polarized secretion to carry out the polarized cell growth. PMID:20175747
Cdc42 regulates Pob1 localization and/or stability. Pob1 interacts with Cdc42. PMID:19710424