Alcam Antibody

1. Our data demonstrate that ALCAM KO mice develop a more severe active experimental autoimmune encephalomyelitis, which can be explained by an increased permeability of their BBB. This loss in BBB integrity is due to a dysregulation of junctional molecules caused by the lack of ALCAM at the level of the TJ molecules. PMID:28069965
2. demonstrates for the first time the in vivo contribution of ALCAM to angiogenesis and reveals a novel role of stromally expressed ALCAM in supporting tumor growth and metastatic spread PMID:28822802
3. Our results indicate that the loss of CD166 impacts hematopoietic stem cell numbers PMID:25730656
4. Data indicate that the CD166/AKT axis modulates tumorigenesis via promotion of phosphorylation and facilitation of degradation, ubiquitination and cytosolic accumulation of FOXO proteins in liver cancer cells. PMID:24891117
5. ALCAM stably interacts with actin by binding to syntenin-1 and ezrin. PMID:24662291
6. CD166/ALCAM (ALCAM) is a close structural and functional homolog of RAGE; it shows that binding of S100B to CD166/ALCAM induces dose- and time-dependent expression of NF-kappaB family members in wild type and RAGE-deficient mouse endothelial cells. PMID:23729438
7. Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166 expression on osteoblasts is directly correlated with Runx2 expression and high hematopoiesis enhancing activity. PMID:23369988
8. Behavioral deficits caused by prolonged IFN alpha treatment were not prevented by blocking ALCAM, which is involved in immune cell entry to the brain. PMID:23178534
9. novel role for ALCAM in stabilizing LEC-LEC interactions and in the organization and function of the LV network. PMID:23169771
10. The presence of CD166 on prostate stem/progenitors and castration resistant sub-populations suggest that it is a cell surface molecule with the potential for targeted delivery of human prostate cancer therapeutics. PMID:22880034
11. CD166 is highly expressed within the endogenous intestinal stem cell niche PMID:20826154
12. The higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite. PMID:20434443
13. ALCAM promotes medial extension of retinal ganglion cell axon branches by interacting with immunoglobulin superfamily adhesion molecule L1. PMID:20016077
14. expression by mesenchymal stem cells in perichondrium PMID:12070283
15. ALCAM is expressed transiently in gonocytes. Sertoli cells and myoid cells also express ALCAM at the same stage. PMID:12781694
16. SC1 mRNA levels increase 5-fold as neurogenesis progresses. PMID:12935912
17. Both motor and retinal ganglion cell axons of BEN-deficient mice fasciculated poorly and were occasionally misdirected. In addition, BEN mutant retinae exhibited evaginated or invaginated regions with photoreceptor ectopias. PMID:15345243
18. We conclude that during sialoadenitis, CD166 undergoes a gain of function, resulting in closer association with the actin cytoskeleton and increased capacity to bind CD6. Altered CD166 function may contribute to the pro-inflammatory milieu . PMID:16418799
19. The transient expression of ALCAM during early developmental stages marks specific developmental stages in cardiomyocyte differentiation. PMID:17409743
20. These results indicate that cells retaining a potential to differentiate to the cardiac lineage are present in E8.5 yolk sacs and can be isolated as ALCAM high+, Flk-1- cells. PMID:17964124
21. ALCAM coordinates tissue growth and cell migration in a process involvnig L1CAM PMID:18483249

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UNIGENE: Mm.288282

KEGG: mmu:11658

STRING: 10090.ENSMUSP00000023312