BCRF1 Antibody

Code: CSB-PA365869ZA01EFA

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Epstein-Barr virus

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P03180

Target Names

BCRF1

Alternative Names

Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)

Raised in

Rabbit

Species Reactivity

Epstein-Barr virus

Immunogen

Recombinant Epstein-Barr virus BCRF1 protein

Immunogen Species

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Conjugate

Non-conjugate

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (12-14 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

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Target Background

Function(From Uniprot)

Plays a role in masking infected cells for immune recognition by cytotoxic T-lymphocytes. Down-regulates the expression of the host TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Inhibits IFN-gamma synthesis.

Gene References into Functions

Our results demonstrate that late genes, BCRF1 and BPLF1, encoding immunomodulatory proteins are transcribed by a mechanism distinct from late genes encoding viral structural proteins PMID:27855219
This viral pre-initiation complex is composed of five different proteins in addition to Epstein-Barr virus BcRF1 and interacts with cellular RNA polymerase II PMID:25165108
Using EBV mutants deficient in BCRF1 and BNLF2a, findings show that both factors contribute to evading EBV-specific immune responses during the earliest phase of infection. PMID:22615564
The authors show here that BcRF1 forms a complex with the TATT motif and that this interaction is required for activation of late viral gene expression. Moreover, our results suggest that BcRF1 acts via interaction with other viral proteins. PMID:22457524
study indicates v-IL10 (BCRF1)is a conserved gene especially in its functional domains; pattern B95-8 is the commonest in Northern China; pattern SPM seems to be associated to EBV-positive nasopharyngeal and laryngopharyngeal epithelial cells PMID:21328379