Atf3 Antibody

Code: CSB-PA112956XA01DLU

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q9XZS8

Target Names

Atf3

Alternative Names

Atf3 antibody; A3-3 antibody; CG11405Activating transcription factor 3 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Atf3 protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Transcription factor which binds to the cAMP response element (CRE). Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut. Required for the expression of odorant receptors Or43b and Or47b.

Gene References into Functions

provide a mechanism to explain how an ATF3-Raw module controls JNK signalling to maintain normal intestinal barrier function during acute infection PMID:28272390
Atf3 controls the microtubule network and plays important role in cell differentiation and cell polarity. PMID:29494583
Loss of Atf3 results in chronic inflammation and starvation responses mounted primarily by the larval gut epithelium, while the fat body suffers lipid overload, causing energy imbalance and death. PMID:22851689

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Subcellular Location

Nucleus.

Protein Families

BZIP family, ATF subfamily

Tissue Specificity

Moderate expression in some regions of the larval nervous system, the ring gland and imaginal disks. High expression in larval gut, excretory malpighian tubules, salivary glands, and, to a lesser extent, the fat body where levels are approximately 2.5-fol

Database Links

KEGG: dme:Dmel_CG11405

STRING: 7227.FBpp0303417

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