ATE1 Antibody

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Component of the N-end rule pathway with ATE2 and PRT6. The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination. The end-rule pathway regulates various aspects of leaf and shoot development. Involved in the oxygen-dependent N-arginylation of RAP2-12, an activator of hypoxic gene expression. This N-terminal modification leads to ubiquitination by PRT6 and subsequent degradation of RAP2-12 under aerobic conditions. Has an important role in the progression of leaf senescence. Involved in disease resistance. The end-rule pathway plays a role in regulating the timing and amplitude of the immune response following infection with the bacterial pathogen Pseudomonas syringae pv tomato. Regulates the biosynthesis of plant-defense metabolites such as glucosinolates, and the biosynthesis and response to the phytohormone jasmonate (JA), which plays a key role in plant immunity.