Anxa1 Antibody

Code: CSB-PA001836XA01RA

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0.1ml

0.1ml1ml

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Species Reactivity: Rattus norvegicus (Rat)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P07150

Target Names

Anxa1

Alternative Names

Anxa1 antibody; Anx1Annexin A1 antibody; Annexin I antibody; Annexin-1 antibody; Calpactin II antibody; Calpactin-2 antibody; Chromobindin-9 antibody; Lipocortin I antibody; Phospholipase A2 inhibitory protein antibody; p35 antibody

Raised in

Rabbit

Species Reactivity

Rattus norvegicus (Rat)

Immunogen

Recombinant Rattus norvegicus (Rat) Anxa1 protein

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing. Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation ofthe formyl peptide receptors. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions. Displays Ca(2+)-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton.

Gene References into Functions

ANXA1 is a novel GnRH target gene in gonadotropes. ANXA1 also may be a target of local GnRH in peripheral tissues and may have a different role than that of ANXA5 PMID:29213013
ANXA1 interacts with p53 and promotes p53 transcriptional activity, which in turn regulates Bid expression. PMID:27584794
ANXA1 promotes microglial activation and migration during oxygen-glucose deprivation/reperfusion via FPR, and CK2 target alpha-E-catenin phosphorylation is involved in this process. PMID:27782092
ANXA1 expression is correlated with TLE activity. Data suggest that ANXA1 plays an important role in TLE by alleviating inflammatory damage and protecting neurons. PMID:26609771
These findings indicated that down-regulation of ANXA2 by siRNA results in the inhibition of the aberrant dysregulation of paxillin and migration of PASMCs, which suggesting a potential therapeutic effect on HPS-associated PVR. PMID:26616057
Silencing Anxa1 with shRNA inhibited the phosphorylation of extracellular signal-regulated kinase 1/2 and the expression of differentiation-associated genes during osteogenesis and resulted in reduced differentiation of mesenchymal stem cells. PMID:26063293
In oxygen-glucose deprivation/reoxygenation, neuronal apoptosis is induced via annexin 1, carried by myosin IIA. PMID:24939696
annexin A1- formyl peptide receptor 2 pathway mediated the insulin resistance of skeletal muscle, as well as systemic insulin sensitivity. PMID:25616869
Findings show that intra-axonal synthesis of p35 is required for normal vesicle recycling in developing neurons, and that targeted translational repression provides a novel strategy to investigate extrasomal protein synthesis in neurons PMID:24254883
ANX A1 down-regulation of PMVEC proliferation in the presence of HPS-rat-serum may be the major cause of aberrant dysregulation of cytoskeletal proteins PMID:23587191
Results suggest that nitric oxide and ANXA1 act in gastric tumors in disparate pathways. PMID:23236538
The data showed that annexin A1 exerts an inhibitory effect on COX-2 expression in the macula densa. ANXA1 may be a novel intrinsic modulator of renal juxtaglomerular regulation by inhibition of PGE2 synthesis. PMID:22791338
Propofol inhibits the activation of p38 through up-regulating the expression of annexin A1 to exert its anti-inflammation effect PMID:22164217
Endogenous ANXA1 expression at the dorsal root ganglion level is involved in complete Freund's adjuvant-induced inflammatory pain, and intrathecal ANXA1 20 microg microl(-1) produces its anti-nociceptive effect through formyl-peptide-receptor-like 1 PMID:21990306
Kirenol upregulates nuclear Annexin-1 which interacts with NF-kappaB to inhibit NF-kappaB activity, reduce cytokine expression and thereby attenuate inflammation of arthritic joints. PMID:21745559
Annexin 1 is able to modulate the reactivity of leukocytes, and more generally, of the experimental inflammatory reaction. PMID:11729999
annexin i is in rat eosinophils and have a different protein mobilisation from extravasated neutrophils, at least in this acute model of peritonitis. PMID:12467520
annexin I is externalized from pituitary folliculo-stellate cells by an ABC transporter and the ATP binding cassette transporter A1 is a likely candidate PMID:12586783
Annexin 1 mediates the disruption of normal cell morphology and inhibits cyclin D1 expression, therefore reducing cell proliferation through proximal modulation of the ERK signal transduction pathway. PMID:14516791
Study reveals increased expression of the annexin 1 isoform at the mRNA level following moderate contusive spinal cord injury. PMID:15248295
the actions of ANXA1 in the pituitary gland are independent of Fpr1 but may involve other FPR family members PMID:17218541
Overexpression of ANNA1 is involved in bladder carcinogenesis induced by bladder calculi and that translocation of the protein may be partly responsible for the effect and as a new marker of differentiation for the histopathological grading of human TCC. PMID:17994624

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Subcellular Location

Nucleus. Cytoplasm. Cell projection, cilium. Basolateral cell membrane. Lateral cell membrane. Cell membrane; Peripheral membrane protein. Apical cell membrane. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Secreted. Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Secreted, extracellular exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup.

Protein Families

Annexin family

Tissue Specificity

Detected in eosinophils. Detected in lung, placenta, spleen and thymus (at protein level).

Database Links

UNIGENE: Rn.1792

KEGG: rno:25380

STRING: 10116.ENSRNOP00000023664

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