Recombinant Human C-X-C motif chemokine 6 protein (CXCL6), partial (Active)

1. CXCL6 could reduce the expression of miR-515-5p in NSCLC cells; MiR-515-5p acted as a tumor suppressor by targeting CXCL6 in non-small cell lung cancer cell cells. PMID:29136957
2. Study has provided the first report of fibroblast-derived CXCL12 enhancement of CXCL6 secretion in colon cancer cells, and of both CXCL12 and CXCL6 co-operatively regulating metastasis through the PI3K/Akt/mTOR signaling pathway. PMID:28811711
3. CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of systemic sclerosis. PMID:28507181
4. CXCL6 level is high in the serum of chronic hepatitis B patients.CXCL6 promotes human hepatocyte proliferation through the CXCR1-NFkappaB pathway and inhibits collagen I secretion by hepatic stellate cells. PMID:27032929
5. The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 and thus affecting immune functions and intraocular pressure. PMID:27520585
6. The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA. PMID:25993443
7. HIF-1alpha promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells. PMID:25323032
8. Expression of the CXCL8, CXCL6 and CXCL1 genes are under the primary control of 1,25-dihydroxyvitamin D3 and its receptor. PMID:24250750
9. Data suggest that expression of CXCL6 in trophoblasts is up-regulated during pregnancy development/placentation; CXCL6 expression inhibits trophoblast cell migration and invasion by down-regulating activity of MMP2 (matrix metalloproteinase 2). PMID:23814098
10. Overexpression of GCP-2 in mesenchymal stem cells has the potential to enhance their angiogenic and survival properties. PMID:22886775
11. Studies show that functional blocking of GCP-2 inhibits tumor growth and metastases. PMID:21236563
12. The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-kappaB, in IL-6 and CXCL8 regulation in Jurkat T-cells. PMID:20507572
13. The level of expression of granulocyte chemotactic protein 2 correlates with the severity of periodontitis and appears to act as a yet unrecognized functional adjunct to interleukin-8 in pathological gingival tissues. PMID:18842116
14. results suggest that granulocyte chemotactic protein-2 is an additional ELR(+)-CXC chemokine expressed in endometrial stromal cells PMID:12524079
15. induction in mesenchymal cells by interleukin-1beta and down-regulation by interferon-gamma PMID:12533683
16. Neutrophil recruitment to inflammatory sites is mediated by two related receptors: CXCR1 and CXCR2. Both receptors share two ligands, interleukin-8 (CXCL8) and GCP-2 (CXCL6). PMID:12628493
17. expression in inflamed intestinal tissue in Crohn's disease PMID:15214047
18. production of GCP-2 by endothelial cells within the tumor can contribute to tumor development through neovascularization due to endothelial cell chemotaxis and to tumor cell invasion and metastasis PMID:15652347
19. LDL lipoprotein subunit L5 induces human umbilical vein endothelial cells (HUVEC) to express CXCL6. PMID:17022986
20. These findings indicate that the equilibrium between angiostatic and angiogenic factors during inflammation and tumor progression is rather complex and differs depending on the chemokine, cell type, and stimulus. PMID:17827342
21. These observations suggest a role for CXCL6 in the innate immune response to microbial invasion of the amniotic cavity. PMID:18782286
22. Report gonadotropin-releasing hormone-regulated CXCL6 expression in human placentation. PMID:19369450

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HGNC: 10643

UNIGENE: Hs.164021

KEGG: hsa:6372

STRING: 9606.ENSP00000226317

OMIM: 138965