VWF

VWF, or von Willebrand factor, is a glycoprotein synthesized mainly in endothelial cells and also by megakaryocytes. It mediates platelet adhesion at sites of vascular injury by binding to the platelet membrane GPⅠb-Ⅸ complex and subcutaneous collagen. VWF also stabilizes factor VIII, acting as its carrier. This factor is central to hemostasis, and its deficiency or dysfunction can result in von Willebrand disease (VWD), a prevalent congenital bleeding disorder. VWF's role in inflammation regulation is also significant in cardiovascular diseases such as atherosclerosis, acute coronary syndrome, and atrial fibrillation.