ZYX

ZYX, or Zyxin, alias ESP-2, HED-2, is a zinc-binding phosphoprotein that is concentrated at adhesion spots and on the actin cytoskeleton.The C-terminal half of the Zyxin protein has an N-terminal proline-rich structural domain and three LIM structural domains.The proline-rich structural domain may interact with the SH3 structural domain of proteins involved in signaling pathways, while the LIM structural domains may be involved in protein-protein binding.
Zyxin acts as a messenger in signal transduction pathways, mediates adhesion-stimulated changes in gene expression, and may regulate the cytoskeletal organization of actin bundles.Zyxin plays a role in a variety of cellular processes, including cell migration, cell adhesion, cytoskeletal dynamics, and signaling.Aberrant expression of Zyxin is associated with a variety of diseases, including tumorigenesis and progression.